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Oncogene

Oncogene

IF:7.3 CiteScore:15.3 Articles:404
Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.

CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression

Published: 25 April 2022 DOI: 10.1038/s41388-022-02318-6
Yang Liu, Yuewen Luo, Shumei Yan, Yi-Fan Lian, Shiyu Wu, Miao Xu, Lin Feng, Xu Zhang, Rong Li, Xiantao Zhang, Qi-Sheng Feng, Yi-Xin Zeng, Hui Zhang

Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling

Published: 7 March 2022 DOI: 10.1038/s41388-022-02256-3
Masayuki Komatsu, Kanako Nakamura, Takashi Takeda, Fumiko Chiwaki, Kouji Banno, Daisuke Aoki, Fumitaka Takeshita, Hiroki Sasaki

Downregulation of LNMAS orchestrates partial EMT and immune escape from macrophage phagocytosis to promote lymph node metastasis of cervical cancer

Published: 12 February 2022 DOI: 10.1038/s41388-022-02202-3
Yuandong Liao, Jiaming Huang, Pan Liu, Chunyu Zhang, Junxiu Liu, Meng Xia, Chunliang Shang, Shiyin Ooi, Yili Chen, Shuhang Qin, Qiqiao Du, Tianyu Liu, Manman Xu, Qiaojian Zou, Yijia Zhou, Hua Huang, Yuwen Pan, Wei Wang, Shuzhong Yao

Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity

Published: 10 February 2022 DOI: 10.1038/s41388-022-02201-4
Tao Zhang, Yu Wang, Qing Li, Liangyu Lin, Chunliang Xu, Yueqing Xue, Mingyuan Hu, Yufang Shi, Ying Wang

METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m6A-YTHDF2-dependent manner.

Published: 29 January 2022 DOI: 10.1038/s41388-022-02185-1
Qiong-Cong Xu, Yi-Chih Tien, Yin-Hao Shi, Siyun Chen, Ying-Qin Zhu, Xi-Tai Huang, Chen-Song Huang, Wei Zhao, Xiao-Yu Yin

Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis

Published: 20 October 2021 DOI: 10.1038/s41388-021-02071-2
Shuyu Yu, Weicheng Zang, Yuchong Qiu, Liming Liao, Xiaofeng Zheng

Wild-type IDH2 protects nuclear DNA from oxidative damage and is a potential therapeutic target in colorectal cancer

Published: 4 August 2021 DOI: 10.1038/s41388-021-01968-2
Shuang Qiao, Wenhua Lu, Christophe Glorieux, Jiangjiang Li, Peiting Zeng, Ning Meng, Huiqin Zhang, Shijun Wen, Peng Huang

CRMP2 is a therapeutic target that suppresses the aggressiveness of breast cancer cells by stabilizing RECK.

Published: 10 August 2020 DOI: 10.1038/s41388-020-01412-x
Binyan Lin, Yongxu Li, Tiepeng Wang, Yangmin Qiu, Zhenzhong Chen, Kai Zhao, Na Lu

MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

Published: 8 November 2019 DOI: 10.1038/s41388-019-1090-1
Chaoyang Sun, Xi Li, Ensong Guo, Na Li, Bo Zhou, Hao Lu, Jia Huang, Meng Xia, Wanying Shan, Beibei Wang, Kezhen Li, Danhui Weng, Xiaoyan Xu, Qinglei Gao, Shixuan Wang, Junbo Hu, Yiling Lu, Gordon B. Mills, Gang Chen
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