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ChemicalBook >> CAS DataBase List >> 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine price.
  • $37 - $2000
  • Product name: 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine
  • CAS: 1254977-87-1
  • MF: C22H23F3N4
  • MW: 400.44
  • EINECS:
  • MDL Number:MFCD22199231
  • Synonyms:3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine;JNJ42153605 (on going);JNJ-42153605;JNJ42153605;CS-2446;3-(Cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluorometh yl)[1,2,4]triazolo[4,3-a]pyridine;1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-;Inhibitor,JNJ42153605,Metabotropic glutamate receptors,JNJ-42153605,inhibit,JNJ 42153605,mGluR;JNJ-42153605 ,S6618
43 prices
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
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  • 10mg
  • 10mM*1mLinDMSO(Solution)
  • 25mg
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  • 1g
  • Manufactureraablocks
  • Product numberAA00A0G3
  • Product descriptionJNJ-42153605 99
  • Packaging2mg
  • Price$45
  • Updated2026-05-28
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  • Manufactureraablocks
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  • Product descriptionJNJ-42153605 99
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  • Price$62
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00A0G3
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  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00A0G3
  • Product descriptionJNJ-42153605 99
  • Packaging25mg
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  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00A0G3
  • Product descriptionJNJ-42153605 99%
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  • Updated2026-05-28
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  • Manufactureraablocks
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  • Updated2026-05-28
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  • Manufactureraablocks
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  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00A0G3
  • Product descriptionJNJ-42153605 99
  • Packaging200mg
  • Price$348
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberY227934
  • Product descriptionJNJ-42153605 97.00%
  • Packaging100MG
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  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberY227934
  • Product descriptionJNJ-42153605 97.00%
  • Packaging25MG
  • Price$160
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product number3032DH
  • Product description3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
  • Packaging1mg
  • Price$139
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberHY-18162
  • Product descriptionJNJ-42153605 99.24%
  • Packaging5mg
  • Price$143
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-18162
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  • Packaging10mM*1mLinDMSO(Solid+Solvent)
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  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-18162
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  • Packaging10mM*1mLinDMSO(Solution)
  • Price$157
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberSLK-S6618
  • Product descriptionJNJ-42153605 99.46%
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  • Updated2026-05-26
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00A0G3 JNJ-42153605 99 2mg $45 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 5mg $62 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 10mg $80 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 25mg $127 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99% 1mg $39 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 50mg $184 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 100mg $254 2026-05-28 Buy
aablocks AA00A0G3 JNJ-42153605 99 200mg $348 2026-05-28 Buy
ACHEMBLOCK Y227934 JNJ-42153605 97.00% 100MG $350 2026-05-27 Buy
ACHEMBLOCK Y227934 JNJ-42153605 97.00% 25MG $160 2026-05-27 Buy
AK Scientific 3032DH 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine 1mg $139 2021-12-16 Buy
Arctom HY-18162 JNJ-42153605 99.24% 5mg $143 2026-05-26 Buy
Arctom HY-18162 JNJ-42153605 99.24% 10mM*1mLinDMSO(Solid+Solvent) $157 2026-05-26 Buy
Arctom HY-18162 JNJ-42153605 99.24% 10mM*1mLinDMSO(Solution) $157 2026-05-26 Buy
Arctom SLK-S6618 JNJ-42153605 99.46% 2mg $93 2026-05-26 Buy
Arctom SLK-S6618 JNJ-42153605 99.46% 5mg $188 2026-05-26 Buy

Properties

Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:30.0(Max Conc. mg/mL);74.92(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.62(Max Conc. mM)
DMSO:10.34(Max Conc. mg/mL);25.81(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);24.97(Max Conc. mM) form :A crystalline solid
pka :3.07±0.30(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2; EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).

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