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ChemicalBook >> CAS DataBase List >> N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide

N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide price.
  • $37 - $3001.8
  • Product name: N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide
  • CAS: 1693731-40-6
  • MF: C32H32N4O5
  • MW: 552.62
  • EINECS:-0
  • MDL Number:MFCD30738050
  • Synonyms:CCT251236;N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide;N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide;CS-2478;CCT251236;CCT-251236;CCT 251236;6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-;CCT-251236,CCT251236;N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide
36 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • AvaChem
  • Axon Medchem
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 5MG
  • 10mM*1mLinDMSO
  • 1mg
  • 10mg
  • 20mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA01ELO8
  • Product descriptionN-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide ≥98%
  • Packaging1mg
  • Price$41
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01ELO8
  • Product descriptionN-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide 98%
  • Packaging10mg
  • Price$91
  • Updated2026-05-30
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD264258
  • Product descriptionCCT251236 98%
  • Packaging5MG
  • Price$100
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD264258
  • Product descriptionCCT251236 98%
  • Packaging25MG
  • Price$245
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number2195EF
  • Product descriptionN-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide
  • Packaging5mg
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number7033
  • Product descriptionCCT251236 >98%
  • Packaging5mg
  • Price$90
  • Updated2026-05-22
  • Buy
  • ManufacturerAvaChem
  • Product number7033
  • Product descriptionCCT251236 >98%
  • Packaging25mg
  • Price$325
  • Updated2026-05-22
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2699
  • Product descriptionCCT251236 99%
  • Packaging5mg
  • Price$159.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2699
  • Product descriptionCCT251236
  • Packaging5mg
  • Price$143
  • Updated2026-05-19
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2699
  • Product descriptionCCT251236
  • Packaging25mg
  • Price$539
  • Updated2026-05-19
  • Buy
  • ManufacturerBiosynth
  • Product numberBC168608
  • Product descriptionCCT 251236
  • Packaging10mg
  • Price$1667.6
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberBC168608
  • Product descriptionCCT 251236
  • Packaging20mg
  • Price$3001.8
  • Updated2026-06-04
  • Buy
  • ManufacturerCayman Chemical
  • Product number27788
  • Product descriptionCCT251236
  • Packaging25mg
  • Price$573
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27788
  • Product descriptionCCT251236 ≥98%
  • Packaging25mg
  • Price$631
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number27788
  • Product descriptionCCT251236
  • Packaging5mg
  • Price$151
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27788
  • Product descriptionCCT251236
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA01ELO8 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide ≥98% 1mg $41 2026-05-30 Buy
aablocks AA01ELO8 N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide 98% 10mg $91 2026-05-30 Buy
ACHEMBLOCK AD264258 CCT251236 98% 5MG $100 2026-05-27 Buy
ACHEMBLOCK AD264258 CCT251236 98% 25MG $245 2026-05-27 Buy
AK Scientific 2195EF N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide 5mg $266 2021-12-16 Buy
AvaChem 7033 CCT251236 >98% 5mg $90 2026-05-22 Buy
AvaChem 7033 CCT251236 >98% 25mg $325 2026-05-22 Buy
Axon Medchem Axon2699 CCT251236 99% 5mg $159.5 2021-12-16 Buy
Axon Medchem Axon2699 CCT251236 5mg $143 2026-05-19 Buy
Axon Medchem Axon2699 CCT251236 25mg $539 2026-05-19 Buy
Biosynth BC168608 CCT 251236 10mg $1667.6 2026-06-04 Buy
Biosynth BC168608 CCT 251236 20mg $3001.8 2026-06-04 Buy
Cayman Chemical 27788 CCT251236 25mg $573 2024-03-01 Buy
Cayman Chemical 27788 CCT251236 ≥98% 25mg $631 2026-04-30 Buy
Cayman Chemical 27788 CCT251236 5mg $151 2024-03-01 Buy
Cayman Chemical 27788 CCT251236 1mg $37 2024-03-01 Buy

Properties

Boiling point :628.7±55.0 °C(Predicted)
Density :1.328±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (5 mg/ml)
form :solid
pka :12.18±0.70(Predicted)
color :Off-white/beige
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

CCT251236 (1693731-40-6) is an inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2
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