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ChemicalBook >> CAS DataBase List >> MRN-ATM Pathway Inhibitor, Mirin

MRN-ATM Pathway Inhibitor, Mirin

MRN-ATM Pathway Inhibitor, Mirin price.
  • $44 - $2050
  • Product name: MRN-ATM Pathway Inhibitor, Mirin
  • CAS: 299953-00-7
  • MF: C10H8N2O2S
  • MW: 220.25
  • EINECS:683-709-3
  • MDL Number:MFCD05885480
  • Synonyms:5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one;MRN-ATM Pathway Inhibitor, Mirin;(5E)-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one;(E)-5-(4-hydroxybenzylidene)-2-iminothiazolidin-4-one;4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-;Mirin >=98% (HPLC), powder;Mirin, MRN-ATM complex inhibitor
52 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • Arctom
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Matrix Scientific
  • Sigma-Aldrich
  • Thermo Scientific Chemicals
  • TRC
Package
  • 10mg
  • 25mg
  • 0.5g
  • 1.00g
  • 2g
  • 2.500g
  • 2.50g
  • 5.00g
  • 5mg
  • 50mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 100mg
  • 250MG
  • 5G
  • 10mM*1mLinDMSO(Solution)
  • 1G
  • Manufactureraablocks
  • Product numberAA007JSZ
  • Product descriptionMirin 99%
  • Packaging50mg
  • Price$86
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007JSZ
  • Product descriptionMirin 99%
  • Packaging100mg
  • Price$143
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA007JSZ
  • Product descriptionMirin ≥95%
  • Packaging5mg
  • Price$49
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD251604
  • Product description2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95%
  • Packaging1G
  • Price$620
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD251604
  • Product description2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95%
  • Packaging5G
  • Price$2050
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberAD251604
  • Product description2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95%
  • Packaging250MG
  • Price$260
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number1860AH
  • Product descriptionMirin
  • Packaging1g
  • Price$656
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberFFG0000171
  • Product descriptionMIRIN 95.00%
  • Packaging5MG
  • Price$607.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberFFG0000171
  • Product descriptionMIRIN 95.00%
  • Packaging100MG
  • Price$1021.14
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$77
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$77
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging5mg
  • Price$71
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging50mg
  • Price$336
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging25mg
  • Price$210
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging100mg
  • Price$546
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-117693
  • Product descriptionMirin 99.22%
  • Packaging10mg
  • Price$113
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA007JSZ Mirin 99% 50mg $86 2026-05-28 Buy
aablocks AA007JSZ Mirin 99% 100mg $143 2026-05-28 Buy
aablocks AA007JSZ Mirin ≥95% 5mg $49 2026-05-28 Buy
ACHEMBLOCK AD251604 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95% 1G $620 2026-05-27 Buy
ACHEMBLOCK AD251604 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95% 5G $2050 2026-05-27 Buy
ACHEMBLOCK AD251604 2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone 95% 250MG $260 2026-05-27 Buy
AK Scientific 1860AH Mirin 1g $656 2021-12-16 Buy
American Custom Chemicals Corporation FFG0000171 MIRIN 95.00% 5MG $607.3 2021-12-16 Buy
American Custom Chemicals Corporation FFG0000171 MIRIN 95.00% 100MG $1021.14 2021-12-16 Buy
Arctom HY-117693 Mirin 99.22% 10mM*1mLinDMSO(Solution) $77 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 10mM*1mLinDMSO(Solid+Solvent) $77 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 5mg $71 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 50mg $336 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 25mg $210 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 100mg $546 2026-05-26 Buy
Arctom HY-117693 Mirin 99.22% 10mg $113 2026-05-26 Buy

Properties

Melting point :295-297 °C(Solv: ethanol (64-17-5))
Boiling point :441.6±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Reddish orange powder
pka :9.15±0.30(Predicted)
color :red to orange
Sensitive :Moisture Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
InChIKey :YBHQCJILTOVLHD-YVMONPNESA-N
SMILES :NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.

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