4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
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- $13 - $2310
- Product name: 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
- CAS: 327036-89-5
- MF: C10H10N2O2S
- MW: 222.26
- EINECS:
- MDL Number:MFCD04973552
- Synonyms:GSK-3InhibitorI,TDZD-8;NP 01139;1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)-;TDZD-8/TDZD8;4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8;TDZD-8, >=98%;TDZD-8;TDZD 8;TDZD8;NP 01139;2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
119 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 1mg
- 10mM(1mLinDMSO)
- 10mM(in1mLDMSO)
- 2mg
- 25mg
- 5mg
- 10mg
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 50mg
- 50.00mg
- 100mg
- 100.00mg
- 200mg
- 250mg
- 250.00mg
- 500mg
- 1000mg
- 1g
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%
- Packaging5mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%
- Packaging10mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione
- Packaging50mg
- Price$121
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione ≥98%
- Packaging100mg
- Price$166
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%(HPLC)
- Packaging250mg
- Price$404
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%(HPLC)
- Packaging1g
- Price$926
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%
- Packaging2mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C6F1
- Product description4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%
- Packaging1mg
- Price$13
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65700
- Product description4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 98%
- Packaging1G
- Price$730
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65700
- Product description4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 98%
- Packaging100MG
- Price$180
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3740-M005
- Product descriptionTDZD-8 ≥98%(HPLC)
- Packaging5mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3740-M025
- Product descriptionTDZD-8 ≥98%(HPLC)
- Packaging25mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3740-M025
- Product descriptionTDZD-8 ≥98%(HPLC)
- Packaging25mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberY0470
- Product descriptionTDZD-8
- Packaging25mg
- Price$188
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0470
- Product descriptionTDZD-8
- Packaging5mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA251413
- Product descriptionTDZD-8 98+%
- Packaging1g
- Price$803
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98% | 5mg | $22 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98% | 10mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione | 50mg | $121 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione ≥98% | 100mg | $166 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%(HPLC) | 250mg | $404 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98%(HPLC) | 1g | $926 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98% | 2mg | $18 | 2026-05-28 | Buy |
| aablocks | AA00C6F1 | 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione 98% | 1mg | $13 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65700 | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 98% | 1G | $730 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65700 | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 98% | 100MG | $180 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3740-M005 | TDZD-8 ≥98%(HPLC) | 5mg | $50 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3740-M025 | TDZD-8 ≥98%(HPLC) | 25mg | $150 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3740-M025 | TDZD-8 ≥98%(HPLC) | 25mg | $90 | 2026-05-06 | Buy |
| AK Scientific | Y0470 | TDZD-8 | 25mg | $188 | 2021-12-16 | Buy |
| AK Scientific | Y0470 | TDZD-8 | 5mg | $59 | 2021-12-16 | Buy |
| Ambeed | A251413 | TDZD-8 98+% | 1g | $803 | 2021-12-16 | Buy |
Properties
Melting point :63-64.4 °C
Boiling point :335.5±35.0 °C(Predicted)
Density :1.375±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
pka :-2.08±0.20(Predicted)
form :needles
color :white
InChI :InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChIKey :JDSJDASOXWCHPN-UHFFFAOYSA-N
SMILES :S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C
Boiling point :335.5±35.0 °C(Predicted)
Density :1.375±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
pka :-2.08±0.20(Predicted)
form :needles
color :white
InChI :InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChIKey :JDSJDASOXWCHPN-UHFFFAOYSA-N
SMILES :S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2 μM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 μM). TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.More related product prices
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