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ChemicalBook >> CAS DataBase List >> 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione price.
  • $10 - $2839
  • Product name: 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
  • CAS: 425637-18-9
  • MF: C25H22N6O2
  • MW: 438.48
  • EINECS:
  • MDL Number:MFCD16038049
  • Synonyms:3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione;Sotrastaurin (AEB071);3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione;Sotrastaurin - AEB 071 | NVP-AEB 071;CS-1479;AEB071; AEB 071; AEB-071;1H-benzo[d][1,2,3]triazol-5-ol;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-
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  • aablocks
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  • Arctom
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  • 2mg
  • 10mM*1mLinDMSO
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  • 50mg
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  • 10mM(in1mLDMSO)
  • 250mg
  • 1G
  • 1000mg
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98%
  • Packaging1mg
  • Price$10
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98%
  • Packaging5mg
  • Price$18
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging10mg
  • Price$33
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging25mg
  • Price$51
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging50mg
  • Price$86
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging100mg
  • Price$137
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging250mg
  • Price$221
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging100MG
  • Price$145
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging25MG
  • Price$50
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging1G
  • Price$850
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberY6229
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
  • Packaging250mg
  • Price$327
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging1MG
  • Price$430
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging5MG
  • Price$550
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging10MG
  • Price$700
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA8525
  • Product descriptionSotrastaurin (AEB071)
  • Packaging50mg
  • Price$935
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA8525
  • Product descriptionSotrastaurin(AEB071)
  • Packaging50mg
  • Price$850
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98% 1mg $10 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98% 5mg $18 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 10mg $33 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 25mg $51 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 50mg $86 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 100mg $137 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 250mg $221 2026-05-28 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 100MG $145 2026-05-27 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 25MG $50 2026-05-27 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 1G $850 2026-05-27 Buy
AK Scientific Y6229 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 250mg $327 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 1MG $430 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 5MG $550 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 10MG $700 2021-12-16 Buy
ApexBio Technology A8525 Sotrastaurin (AEB071) 50mg $935 2026-05-06 Buy
ApexBio Technology A8525 Sotrastaurin(AEB071) 50mg $850 2021-12-16 Buy

Properties

Density :1.406
storage temp. :Store at -20°C
solubility :≥21.9 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with ultrasonic
form :solid
pka :7.39±0.60(Predicted)
color :Pink to red
InChI :1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
InChIKey :OAVGBZOFDPFGPJ-UHFFFAOYSA-N
SMILES :N1C(=O)C(C2=C3C(=NC(N4CCN(C)CC4)=N2)C=CC=C3)=C(C2C3=C(NC=2)C=CC=C3)C1=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Sotrastaurin is a protein kinase C (PKC) inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling. In cell-free assays, sotrastaurin was reported to inhibit PKCα, βI, δ, ε, η, and θ with Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM, respectively. Sotrastaurin can prevent the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. However, clinical investigation of sotrastaurin for its potential to prevent renal transplant rejection was halted during phase II testing due to high incidence of rejection. Sotrastaurin is also reported to activate Wnt/β-catenin signaling via the inhibition of glycogen synthase kinase 3 (IC50s = 229 and 172 nM for α and β isoforms, respectively), which is essential for embryogenesis and adult stem cell maintenance.

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