N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
![N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide price.](/CAS2/GIF/717906-29-1.gif)
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- $32 - $2200
- Product name: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
- CAS: 717906-29-1
- MF: C22H21F3N6O3S
- MW: 506.5
- EINECS:
- MDL Number:MFCD16038300
- Synonyms:N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide;N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]phenyl]-N-MethylMethanesulfonaMide;N-methyl-N-(2-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)phenyl)methanesulfonamide;N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF-431396;N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-Methanesulfonamide hydrate;PF-431396 hydrate;PF 431396, >=98%;PF-431396;PF431396
73 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 5mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 2x5mg
- 25mg
- 50mg
- 200mg
- 10mM*1mLinDMSO
- 100MG
- 250mg
- 10mM(in1mLDMSO)
- 1g
- 5g
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA005FEE
- Product descriptionPF-431396 99%
- Packaging25mg
- Price$85
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA005FEE
- Product descriptionPF-431396 99%
- Packaging50mg
- Price$110
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA005FEE
- Product descriptionPF-431396 99%
- Packaging5mg
- Price$43
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA005FEE
- Product descriptionPF-431396 99%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA005FEE
- Product descriptionPF-431396 99%
- Packaging10mg
- Price$63
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65813
- Product descriptionN-methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98%
- Packaging100MG
- Price$215
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65813
- Product descriptionN-methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2568AH
- Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate
- Packaging5g
- Price$1072
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2637AH
- Product descriptionN-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide
- Packaging250mg
- Price$1204
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging5mg
- Price$54
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging1mg
- Price$45
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging25mg
- Price$107
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging10mg
- Price$79
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging50mg
- Price$139
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging100mg
- Price$222
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA325541
- Product descriptionPF-431396 99%
- Packaging250mg
- Price$375
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA005FEE | PF-431396 99% | 25mg | $85 | 2026-05-28 | Buy |
| aablocks | AA005FEE | PF-431396 99% | 50mg | $110 | 2026-05-28 | Buy |
| aablocks | AA005FEE | PF-431396 99% | 5mg | $43 | 2026-05-28 | Buy |
| aablocks | AA005FEE | PF-431396 99% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA005FEE | PF-431396 99% | 10mg | $63 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65813 | N-methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98% | 100MG | $215 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65813 | N-methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide 98% | 25MG | $110 | 2026-05-27 | Buy |
| AK Scientific | 2568AH | N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)Amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamidehydrate | 5g | $1072 | 2021-12-16 | Buy |
| AK Scientific | 2637AH | N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methanesulfonamide | 250mg | $1204 | 2021-12-16 | Buy |
| Ambeed | A325541 | PF-431396 99% | 5mg | $54 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 1mg | $45 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 25mg | $107 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 10mg | $79 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 50mg | $139 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 100mg | $222 | 2026-06-05 | Buy |
| Ambeed | A325541 | PF-431396 99% | 250mg | $375 | 2026-06-05 | Buy |
Properties
Density :1.506
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
InChIKey :XSXCARUUZVMRGX-UHFFFAOYSA-N
SMILES :O.CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(C)(=O)=O
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
pka :13.66±0.20(Predicted)
color :off-white to blue-gray
InChIKey :XSXCARUUZVMRGX-UHFFFAOYSA-N
SMILES :O.CN(c1ccccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(C)(=O)=O
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption. PF-431396 is a pyrimidine-based dual inhibitor of FAK and PYK2 (IC50s = 2 and 11 nM, respectively). In ovariectomized rats, it has been shown to increase bone formation, promoting osteoblast recruitment and activity.More related product prices
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![N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide](https://img.chemicalbook.com/ProductImageEN/2018-8/small/1a2acf69-077d-47a2-a6d9-c4ee16bb0d03.jpg){kind=small}
