3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
![3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione price.](/CAS/GIF/905854-02-6.gif)
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- $16 - $8042
- Product name: 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
- CAS: 905854-02-6
- MF: C23H19N3O2
- MW: 369.42
- EINECS:
- MDL Number:MFCD11977597
- Synonyms:3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib;3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione;(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;TIVANTINIB ARQ-197;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione;Tivantinib/ARQ197/ARQ-197;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dio;2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- JR MediChem
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 10mg
- 20mg
- 25MG
- 1unit
- 1mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 50mg
- 100mg
- 200mg
- 10mM(in1mLDMSO)
- 250.00mg
- EvaluationSample
- 250mg
- 500mg
- 1G
- 1.00g
- Manufactureraablocks
- Product numberAA0036RS
- Product description(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99
- Packaging100mg
- Price$314
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036RS
- Product description(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99%
- Packaging5mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036RS
- Product description(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10396
- Product descriptionTivantinib 98%
- Packaging1G
- Price$2650
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10396
- Product descriptionTivantinib 98%
- Packaging100MG
- Price$330
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10396
- Product descriptionTivantinib 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10396
- Product descriptionTivantinib 98%
- Packaging25MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5688
- Product descriptionTivantinib
- Packaging50mg
- Price$617
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5688
- Product descriptionTivantinib
- Packaging100mg
- Price$1053
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0311
- Product descriptionTivantinib
- Packaging1g
- Price$8042
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA891951
- Product descriptionTivantinib 98+%
- Packaging10mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA891951
- Product descriptionTivantinib 98+%
- Packaging5mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib(ARQ197)
- Packaging100mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib (ARQ 197)
- Packaging100mg
- Price$380
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib(ARQ197)
- Packaging20mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8325
- Product descriptionTivantinib (ARQ 197)
- Packaging20mg
- Price$120
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0036RS | (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99 | 100mg | $314 | 2026-05-28 | Buy |
| aablocks | AA0036RS | (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99% | 5mg | $19 | 2026-05-28 | Buy |
| aablocks | AA0036RS | (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 99% | 1mg | $16 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10396 | Tivantinib 98% | 1G | $2650 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10396 | Tivantinib 98% | 100MG | $330 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10396 | Tivantinib 98% | 5MG | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10396 | Tivantinib 98% | 25MG | $130 | 2026-05-27 | Buy |
| AK Scientific | SYN5688 | Tivantinib | 50mg | $617 | 2021-12-16 | Buy |
| AK Scientific | SYN5688 | Tivantinib | 100mg | $1053 | 2021-12-16 | Buy |
| AK Scientific | Y0311 | Tivantinib | 1g | $8042 | 2021-12-16 | Buy |
| Ambeed | A891951 | Tivantinib 98+% | 10mg | $67 | 2021-12-16 | Buy |
| Ambeed | A891951 | Tivantinib 98+% | 5mg | $45 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib(ARQ197) | 100mg | $380 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib (ARQ 197) | 100mg | $380 | 2026-05-06 | Buy |
| ApexBio Technology | A8325 | Tivantinib(ARQ197) | 20mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8325 | Tivantinib (ARQ 197) | 20mg | $120 | 2026-05-06 | Buy |
Properties
Boiling point :715.9±60.0 °C(Predicted)
Density :1.49
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.28±0.70(Predicted)
form :Solid
color :Light Orange
Density :1.49
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.28±0.70(Predicted)
form :Solid
color :Light Orange
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. Tivantinib is a staurosporine derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known. Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met. However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met. Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.More related product prices
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