ADX-47273
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- $16 - $2442
- Product name: ADX-47273
- CAS: 851881-60-2
- MF: C20H17F2N3O2
- MW: 369.36
- EINECS:
- MDL Number:MFCD17167026
- Synonyms:ADX-47273;(S)-(4-Fluorophenyl)-{3-[3-(4-fluorophenyl)-[1,2,4]oxadiazol-5-yl]piperidin-1-yl}methanone;BA 94673139;ADX47273, >98%;ADX-47273;ADX47273;CS-221;ADX-47273 >=98% (HPLC);(3S)-3-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(4-fluorophenyl)carbonyl]piperidine
66 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Usbiological
Package
- 10mM(1mLinDMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 10mM*1mLinDMSO
- 25.00mg
- 50.00mg
- 50mg
- 100MG
- 100.00mg
- 200mg
- 250MG
- 1g
- Manufactureraablocks
- Product numberAA00G3A4
- Product description(S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone ≥98%
- Packaging50mg
- Price$62
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3A4
- Product description(S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98%
- Packaging10mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3A4
- Product description(S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98%
- Packaging5mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00G3A4
- Product description(S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33840
- Product descriptionADX 47273 98%
- Packaging100MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33840
- Product descriptionADX 47273 98%
- Packaging250MG
- Price$350
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7599
- Product description(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
- Packaging10mg
- Price$164
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7599
- Product description(S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
- Packaging50mg
- Price$451
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging1g
- Price$841
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging250mg
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging100mg
- Price$212
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging50mg
- Price$163
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging10mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA217506
- Product descriptionADX-47273 99+%
- Packaging25mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBIO0000304
- Product descriptionADX-47273 95.00%
- Packaging5MG
- Price$495.14
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00G3A4 | (S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone ≥98% | 50mg | $62 | 2026-05-28 | Buy |
| aablocks | AA00G3A4 | (S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98% | 10mg | $34 | 2026-05-28 | Buy |
| aablocks | AA00G3A4 | (S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98% | 5mg | $28 | 2026-05-28 | Buy |
| aablocks | AA00G3A4 | (S)-(4-Fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone 98% | 1mg | $16 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33840 | ADX 47273 98% | 100MG | $175 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33840 | ADX 47273 98% | 250MG | $350 | 2026-05-27 | Buy |
| AK Scientific | X7599 | (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone | 10mg | $164 | 2021-12-16 | Buy |
| AK Scientific | X7599 | (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone | 50mg | $451 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 1g | $841 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 250mg | $351 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 100mg | $212 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 50mg | $163 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 10mg | $66 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 5mg | $41 | 2021-12-16 | Buy |
| Ambeed | A217506 | ADX-47273 99+% | 25mg | $125 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BIO0000304 | ADX-47273 95.00% | 5MG | $495.14 | 2021-12-16 | Buy |
Properties
Boiling point :540.8±60.0 °C(Predicted)
Density :1.311
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :-0.83±0.44(Predicted)
color :White to off-white
optical activity :[α]/D +90 to +110°, c =0.1 in chloroform-d
InChI :1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
InChIKey :VXQCCZHCFBHTTD-HNNXBMFYSA-N
SMILES :FC1=CC=C(C=C1)C2=NOC([C@@H]3CN(CCC3)C(C4=CC=C(C=C4)F)=O)=N2
Density :1.311
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Powder
pka :-0.83±0.44(Predicted)
color :White to off-white
optical activity :[α]/D +90 to +110°, c =0.1 in chloroform-d
InChI :1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1
InChIKey :VXQCCZHCFBHTTD-HNNXBMFYSA-N
SMILES :FC1=CC=C(C=C1)C2=NOC([C@@H]3CN(CCC3)C(C4=CC=C(C=C4)F)=O)=N2
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
ADX-47273 is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with EC50 values of 0.17 and 0.23 μM for potentiation of glutamate activity in HEK293 cells expressing rat mGluR5 and primary astrocyte cultures, respectively. It is selective for mGluR5 over rat mGluR1 and human mGluR1 and mGluR4 when used at concentrations up to 10 μM. In vivo, ADX-47273 (1 and 10 mg/kg, i.p.) increases ERK and CREB phosphorylation in the hippocampus and prefrontal cortex in rats. It decreases the conditioned avoidance response, apomorphine-induced climbing, as well as PCP-, apomorphine-, and amphetamine-induced locomotor activity in rats in a dose-dependent manner, indicating antipsychotic-like activity. ADX-47273 (0.1-50 mg/kg, i.p) improves recall in a novel object recognition test and reduces impulsivity in the 5-choice serial reaction time task (5CSRTT). It also enhances reversal learning in mice in the Morris water maze test.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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Zhejiang J&C Biological Technology Co.,Limited
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ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
