APICIDIN
|
- $50 - $4162
- Product name: APICIDIN
- CAS: 183506-66-3
- MF: C34H49N5O6
- MW: 623.78
- EINECS:
- MDL Number:MFCD26142628
- Synonyms:APICIDIN, FUSARIUM SPECIES;Ccris 9163;Apicidin Ia;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];OSI 2040;Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];CYCLO-L-(2-AMINO-8-OXODEACANOYL)-L-(N-METHOXY-TRYPTOPHAN)-L-ISOLEUCYL-D-PIPECOLINYL
57 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 2mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- Manufactureraablocks
- Product numberAA0027JV
- Product descriptionApicidin ≥90%
- Packaging1mg
- Price$66
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027JV
- Product descriptionApicidin ≥90%
- Packaging10mg
- Price$473
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027JV
- Product descriptionApicidin ≥90%
- Packaging5mg
- Price$253
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264238
- Product descriptionApicidin 98%
- Packaging5MG
- Price$460
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264238
- Product descriptionApicidin 98%
- Packaging1MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0087-M001
- Product descriptionApicidin ≥98%(HPLC,TLC)
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0087-M001
- Product descriptionApicidin ≥98%(HPLC,TLC)
- Packaging1mg
- Price$65
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0087-M005
- Product descriptionApicidin ≥98%(HPLC,TLC)
- Packaging5mg
- Price$260
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8176
- Product descriptionApicidin
- Packaging1mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8176
- Product descriptionApicidin
- Packaging10mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8176
- Product descriptionApicidin
- Packaging5mg
- Price$460
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8176
- Product descriptionApicidin
- Packaging10mg
- Price$637
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBIA4318
- Product descriptionApicidin
- Packaging25mg
- Price$1265
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIA4318
- Product descriptionApicidin
- Packaging50mg
- Price$2295
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIA4318
- Product descriptionApicidin
- Packaging100mg
- Price$4162
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIA4318
- Product descriptionApicidin
- Packaging5mg
- Price$240
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0027JV | Apicidin ≥90% | 1mg | $66 | 2026-05-28 | Buy |
| aablocks | AA0027JV | Apicidin ≥90% | 10mg | $473 | 2026-05-28 | Buy |
| aablocks | AA0027JV | Apicidin ≥90% | 5mg | $253 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264238 | Apicidin 98% | 5MG | $460 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD264238 | Apicidin 98% | 1MG | $145 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CN2-0087-M001 | Apicidin ≥98%(HPLC,TLC) | 1mg | $50 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0087-M001 | Apicidin ≥98%(HPLC,TLC) | 1mg | $65 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CN2-0087-M005 | Apicidin ≥98%(HPLC,TLC) | 5mg | $260 | 2026-05-06 | Buy |
| ApexBio Technology | A8176 | Apicidin | 1mg | $120 | 2026-05-06 | Buy |
| ApexBio Technology | A8176 | Apicidin | 10mg | $478 | 2021-12-16 | Buy |
| ApexBio Technology | A8176 | Apicidin | 5mg | $460 | 2026-05-06 | Buy |
| ApexBio Technology | A8176 | Apicidin | 10mg | $637 | 2026-05-06 | Buy |
| Apolloscientific | BIA4318 | Apicidin | 25mg | $1265 | 2026-06-04 | Buy |
| Apolloscientific | BIA4318 | Apicidin | 50mg | $2295 | 2026-06-04 | Buy |
| Apolloscientific | BIA4318 | Apicidin | 100mg | $4162 | 2026-06-04 | Buy |
| Apolloscientific | BIA4318 | Apicidin | 5mg | $240 | 2021-12-16 | Buy |
Properties
Melting point :188-190oC
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: ~1mg/mL
pka :13.09±0.70(Predicted)
form :solid
color :White
biological source :microbial
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
InChIKey :JWOGUUIOCYMBPV-PYAAAQPJSA-N
SMILES :[H][C@]12CCCCN1C(=O)[C@@H](NC(=O)[C@H](Cc3cn(OC)c4ccccc34)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :DMSO: ~1mg/mL
pka :13.09±0.70(Predicted)
form :solid
color :White
biological source :microbial
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. Compound is prone to oxidation. Protect from exposure to air.
InChIKey :JWOGUUIOCYMBPV-PYAAAQPJSA-N
SMILES :[H][C@]12CCCCN1C(=O)[C@@H](NC(=O)[C@H](Cc3cn(OC)c4ccccc34)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
Histone acetyltransferase and histone deacetylase (HDAC) activity regulates the reversible acetylation of lysine residues within histone tails, which results in either transcriptional activation or repression of nearby genes. Compounds that modulate this activity are of interest in cancer chemotherapeutics as well as for treating psychiatric disorders, malaria, and other diseases. Apicidin is a fungal toxin that has broad spectrum activity against Apicomplexan parasites through inhibiting HDACs (IC50 = 0.7 nM). An in vitro activity assay demonstrates apicidin inhibition of HDAC3/NcoR, a class I HDAC, at a much higher potency than for class II HDAC6 (IC50s = 15.8 and 665.1 nM, respectively). Apicidin exhibits antiproliferative activity against various cancer cell lines (IC50s = 0.13-2.36 μM), and at 0.5 – 2 μM it induces selective changes in p21WAF1/Cip1 and gelsolin gene expression, which control cell cycle and cell morphology, respectively.Related product price
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