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ChemicalBook >> CAS DataBase List >> CAY10603

CAY10603

$23 - $2970
Product name: CAY10603
CAS: 1045792-66-2
MF: C22H30N4O6
MW: 446.5
EINECS:
MDL Number:MFCD17010286
Synonyms:N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester;HDAC6 inhibitor ISOX;CAY10603;Isox;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate;HDAC6 Inhibitor;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;CAY10603; CAY-10603; CAY 10603.

Price56 Properties Safety Information Description

56 prices

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Brand

aablocks
ACHEMBLOCK
ApexBio Technology
Axon Medchem
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
TRC

Package

10mM(in1mLDMSO)
1000μg
1mg
250mg
10mM*1mLinDMSO
1 mg
1 unit
10mM(in 1mL DMSO)
500μg
5mg
10mg
25mg
50mg
100mg
1G

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging1mg
Price$23
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging5mg
Price$47
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging10mg
Price$76
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging25mg
Price$141
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging50mg
Price$239
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA007XO8
Product descriptionCarbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%
Packaging100mg
Price$407
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging25MG
Price$170
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging25MG
Price$170
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging100MG
Price$495
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging100MG
Price$495
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging1G
Price$2970
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberT101397
Product descriptiontert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%
Packaging1G
Price$2970
Updated2026-05-27
Buy

ManufacturerApexBio Technology
Product numberB4856
Product descriptionCAY10603
Packaging5mg
Price$105
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB4856
Product descriptionCAY10603
Packaging5mg
Price$116
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberB4856
Product descriptionCAY10603
Packaging10mM(in 1mL DMSO)
Price$120
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB4856
Product descriptionCAY10603
Packaging10mM(in1mLDMSO)
Price$121
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	1mg	$23	2026-05-28	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	5mg	$47	2026-05-28	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	10mg	$76	2026-05-28	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	25mg	$141	2026-05-28	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	50mg	$239	2026-05-28	Buy
aablocks	AA007XO8	Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester 98%	100mg	$407	2026-05-28	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	25MG	$170	2026-05-25	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	25MG	$170	2026-05-27	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	100MG	$495	2026-05-25	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	100MG	$495	2026-05-27	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	1G	$2970	2026-05-25	Buy
ACHEMBLOCK	T101397	tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate 98%	1G	$2970	2026-05-27	Buy
ApexBio Technology	B4856	CAY10603	5mg	$105	2021-12-16	Buy
ApexBio Technology	B4856	CAY10603	5mg	$116	2026-05-06	Buy
ApexBio Technology	B4856	CAY10603	10mM(in 1mL DMSO)	$120	2021-12-16	Buy
ApexBio Technology	B4856	CAY10603	10mM(in1mLDMSO)	$121	2026-05-06	Buy

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Properties

Density :1.231±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form :Beige to light brown solid
pka :9.47±0.20(Predicted)
color :White to light yellow
InChIKey :WWGBHDIHIVGYLZ-UHFFFAOYSA-N
SMILES :N(O)C(=O)CCCCCCNC(=O)c1n[o]c(c1)c2ccc(cc2)NC(=O)OC(C)(C)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

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Suppliers and manufacturers

TargetMol Chemicals Inc.

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CAY10603

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