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ChemicalBook >> CAS DataBase List >> Defactinib

Defactinib

$13 - $2175
Product name: Defactinib
CAS: 1073154-85-4
MF: C20H21F3N8O3S
MW: 510.49
EINECS:
MDL Number:
Synonyms:Defactinib;VS 6063;VS-6063;Defactinib(PF-04554878);N-methyl-4-(4-((3-(N-methylmethan-3-ylsulfonamido)pyrazin-2-yl)methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)benzamide;N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide;N-METHYL-4-(4-((3-(N-METHYLMETHYL SULFON;N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide

Price80 Properties Safety Information Description

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aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
TRC
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Package

10mM(1mLinDMSO)
1mg
5mg
10mM*1mLinDMSO
10mg
25.00mg
25mg
50.00mg
50mg
100.00mg
100mg
200mg
250mg
1g
1000mg
5g

Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%
Packaging1mg
Price$13
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide ≥98%
Packaging5mg
Price$16
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide ≥98%
Packaging10mg
Price$29
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%
Packaging25mg
Price$54
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%
Packaging50mg
Price$91
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%
Packaging100mg
Price$119
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%
Packaging250mg
Price$198
Updated2026-05-28
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Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 98%
Packaging1g
Price$729
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008TCN
Product descriptionN-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 98%
Packaging5g
Price$2175
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging1G
Price$650
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging1G
Price$650
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging100MG
Price$140
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging100MG
Price$140
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging25MG
Price$60
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberM22547
Product descriptionDefactinib 98%
Packaging25MG
Price$60
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberSYN5745
Product descriptionDefactinib
Packaging50mg
Price$617
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%	1mg	$13	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide ≥98%	5mg	$16	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide ≥98%	10mg	$29	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%	25mg	$54	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%	50mg	$91	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%	100mg	$119	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 99%	250mg	$198	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 98%	1g	$729	2026-05-28	Buy
aablocks	AA008TCN	N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide 98%	5g	$2175	2026-05-28	Buy
ACHEMBLOCK	M22547	Defactinib 98%	1G	$650	2026-05-25	Buy
ACHEMBLOCK	M22547	Defactinib 98%	1G	$650	2026-05-27	Buy
ACHEMBLOCK	M22547	Defactinib 98%	100MG	$140	2026-05-25	Buy
ACHEMBLOCK	M22547	Defactinib 98%	100MG	$140	2026-05-27	Buy
ACHEMBLOCK	M22547	Defactinib 98%	25MG	$60	2026-05-25	Buy
ACHEMBLOCK	M22547	Defactinib 98%	25MG	$60	2026-05-27	Buy
AK Scientific	SYN5745	Defactinib	50mg	$617	2021-12-16	Buy

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Properties

Density :1.495±0.06 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to at least 25mg/ml)
pka :15.16±0.46(Predicted)
form :solid
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :FWLMVFUGMHIOAA-UHFFFAOYSA-N
SMILES :C(NC)(=O)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(C)(=O)=O)=N2)C=C1

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a vital role in many oncogenic pathways. Defactinib is a dose-dependent inhibitor of FAK, with maximal inhibition of FAK autophosphorylation in cells achieved at 10 μM. It is less effective against the related kinase Pyk2. Defactinib restores the chemosensitivity of taxane-resistant cells to paclitaxel , although it is not cytotoxic alone. Defactinib decreases YB-1 phosphorylation and nuclear accumulation in an Akt-dependent manner. It is orally bioavailable, inhibiting FAK and augmenting paclitaxel action in suppressing the growth and number of ovarian cancer cell tumors in mice.

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Suppliers and manufacturers

career henan chemical co

$1.00
Defactinib CAS:1073154-85-4

ATK CHEMICAL COMPANY LIMITED

TargetMol Chemicals Inc.

HANGZHOU CLAP TECHNOLOGY CO.,LTD

BOC Sciences

Zhejiang J&C Biological Technology Co.,Limited

InvivoChem

HANGZHOU LEAP CHEM CO., LTD.

Coresyn Pharmatech Co., Ltd.

Nantong HI-FUTURE Biology Co., Ltd.

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Defactinib

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