IMD-0354
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- $12 - $1528
- Product name: IMD-0354
- CAS: 978-62-1
- MF: C15H8ClF6NO2
- MW: 383.67
- EINECS:
- MDL Number:MFCD00218820
- Synonyms:Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354
80 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 1mg
- 10mg
- 10mM*1mLinDMSO
- 5mg
- 10mM*1mLinDMSO(Solution)
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5G
- EvaluationSample
- 50.00g
- 100.00g
- 250.00g
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98%
- Packaging50mg
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98%
- Packaging100mg
- Price$95
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98%
- Packaging250mg
- Price$143
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 95%
- Packaging1g
- Price$507
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide ≥99%
- Packaging10mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide ≥99%
- Packaging5mg
- Price$13
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036P9
- Product descriptionN-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY218746
- Product descriptionN-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 95.00%
- Packaging5G
- Price$920
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY218746
- Product descriptionN-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 95.00%
- Packaging1G
- Price$230
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2473AH
- Product descriptionIMD0354
- Packaging1g
- Price$1269
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging1g
- Price$1528
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging100mg
- Price$392
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging250mg
- Price$593
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging50mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging10mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA232738
- Product descriptionIMD-0354 98+%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98% | 50mg | $77 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98% | 100mg | $95 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98% | 250mg | $143 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 95% | 1g | $507 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide ≥99% | 10mg | $23 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide ≥99% | 5mg | $13 | 2026-05-28 | Buy |
| aablocks | AA0036P9 | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide 98% | 1mg | $12 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y218746 | N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 95.00% | 5G | $920 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y218746 | N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 95.00% | 1G | $230 | 2026-05-27 | Buy |
| AK Scientific | 2473AH | IMD0354 | 1g | $1269 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 1g | $1528 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 100mg | $392 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 250mg | $593 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 50mg | $202 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 10mg | $87 | 2021-12-16 | Buy |
| Ambeed | A232738 | IMD-0354 98+% | 1mg | $33 | 2021-12-16 | Buy |
Properties
Boiling point :323.1±42.0 °C(Predicted)
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
pka :7.61±0.43(Predicted)
form :White solid
color :White to off-white
Sensitive :Light Sensitive
InChI :1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChIKey :CHILCFMQWMQVAL-UHFFFAOYSA-N
SMILES :Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
CAS DataBase Reference :978-62-1
Density :1.561
storage temp. :-20°C
solubility :DMSO (5 mg/ml) or Ethanol (1 mg/ml).
pka :7.61±0.43(Predicted)
form :White solid
color :White to off-white
Sensitive :Light Sensitive
InChI :1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
InChIKey :CHILCFMQWMQVAL-UHFFFAOYSA-N
SMILES :Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
CAS DataBase Reference :978-62-1
Safety Information
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Description
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.More related product prices
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