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ChemicalBook >> CAS DataBase List >> IXABEPILONE

IXABEPILONE

IXABEPILONE price.
  • $61 - $5803.8
  • Product name: IXABEPILONE
  • CAS: 219989-84-1
  • MF: C27H42N2O5S
  • MW: 506.7
  • EINECS:630-424-7
  • MDL Number:MFCD04307791
  • Synonyms:IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Unii-K27005np0a;Azi-epothilone B;BMS 247550
64 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
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  • Cayman Chemical
  • Chemenu
  • ChemScene
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  • DC Chemicals
  • Sigma-Aldrich
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Package
  • 10mM(1mLinDMSO)
  • 2mg
  • 10mM(in1mLDMSO)
  • 1mg
  • 10mM(in 1mL DMSO)
  • 10mM*1mLinDMSO
  • 2.5mg
  • 5mg
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  • 1g
  • 5 mg
  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging10mg
  • Price$256
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98
  • Packaging25mg
  • Price$492
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging5mg
  • Price$145
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98
  • Packaging2mg
  • Price$96
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98%
  • Packaging1mg
  • Price$61
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98
  • Packaging50mg
  • Price$706
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98
  • Packaging100mg
  • Price$940
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00BE4S
  • Product description(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98
  • Packaging200mg
  • Price$1260
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberZ238790
  • Product descriptionIxabepilone 98%
  • Packaging25MG
  • Price$465
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberZ238790
  • Product descriptionIxabepilone 98%
  • Packaging5MG
  • Price$180
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberX7258
  • Product descriptionIxabepilone
  • Packaging50mg
  • Price$1605
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004751
  • Product descriptionIXABEPILONE 95.00%
  • Packaging25MG
  • Price$2182.95
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0004751
  • Product descriptionIXABEPILONE 95.00%
  • Packaging5MG
  • Price$715
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3513
  • Product descriptionIxabepilone
  • Packaging10mM(in 1mL DMSO)
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3513
  • Product descriptionIxabepilone
  • Packaging10mM(in1mLDMSO)
  • Price$245
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3513
  • Product descriptionIxabepilone
  • Packaging5mg
  • Price$220
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98% 10mg $256 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98 25mg $492 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98% 5mg $145 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98 2mg $96 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98% 1mg $61 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98 50mg $706 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98 100mg $940 2026-05-28 Buy
aablocks AA00BE4S (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione 98 200mg $1260 2026-05-28 Buy
ACHEMBLOCK Z238790 Ixabepilone 98% 25MG $465 2026-05-27 Buy
ACHEMBLOCK Z238790 Ixabepilone 98% 5MG $180 2026-05-27 Buy
AK Scientific X7258 Ixabepilone 50mg $1605 2021-12-16 Buy
American Custom Chemicals Corporation API0004751 IXABEPILONE 95.00% 25MG $2182.95 2021-12-16 Buy
American Custom Chemicals Corporation API0004751 IXABEPILONE 95.00% 5MG $715 2021-12-16 Buy
ApexBio Technology A3513 Ixabepilone 10mM(in 1mL DMSO) $245 2021-12-16 Buy
ApexBio Technology A3513 Ixabepilone 10mM(in1mLDMSO) $245 2026-05-06 Buy
ApexBio Technology A3513 Ixabepilone 5mg $220 2026-05-06 Buy

Properties

Melting point :>160°C (dec.)
alpha :D22 -40.7° (c = 1.0 in chloroform)
Boiling point :697.8±55.0 °C(Predicted)
Density :1.122±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :13.73±0.70(Predicted)
form :White solid.
color :White to Off-White
InChIKey :FABUFPQFXZVHFB-PVYNADRNSA-N
SMILES :[C@]12([H])[C@](C)(O1)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)N[C@H](/C(/C)=C/C1=CSC(C)=N1)C2

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ixabepilone, a semisynthetic analog of epothilone B, was launched for the treatment of metastatic or locally advanced breast cancer. It is indicated for use in combination with capecitabine in patients who have previously failed treatment with an anthracycline such as doxorubicin and a taxane such as paclitaxel. It is also approved as monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine. Ixabepilone is the first member of the epothilone family of anticancer agents to be approved. Epothilones are novel cytotoxic macrolides derived from bacterial fermentation.
Like the taxanes, their mechanism of action involves binding to and stabilizing microtubules, which results in mitotic arrest and apoptosis.
The most common adverse reactions (X20%) associated with ixabelipone as monotherapy or in combination with capecitabine were peripheral sensory neuropathy, fatigue/asthenia, myalgia/arthralgia, alopecia, nausea, vomiting, stomatitis/ mucositis, diarrhea, and musculoskeletal pain. The most common hematologic abnormalities (W 40%) include neutropenia, leukopenia, anemia, and thrombocytopenia. Ixabelipone in combination with capecitabine is contraindicated in patients with AST or ALT W2.5 ULN (upper limit of normal) or bilirubin W1 ULN due to increased risk of toxicity and neutropenia-related death.

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