PF-04929113
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- $10 - $7000
- Product name: PF-04929113
- CAS: 908115-27-5
- MF: C25H30F3N5O4
- MW: 521.53
- EINECS:
- MDL Number:MFCD20526334
- Synonyms:(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;PF-04929113, >=98%;snx54227;PF04929113 SNX-54227;PF-04929113;PF-04929113(SNX5422);Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester;CS-33
59 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mM(in1mLDMSO)
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 1g
- 5g
- 10g
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98%
- Packaging1mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98%
- Packaging5mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98%
- Packaging10mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98%
- Packaging25mg
- Price$74
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98%
- Packaging50mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0R3
- Product descriptiontrans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate 98%
- Packaging1g
- Price$2197
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228761
- Product descriptionPF04929113 97.00%
- Packaging25MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228761
- Product descriptionPF04929113 97.00%
- Packaging100MG
- Price$435
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7589
- Product description(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate
- Packaging10mg
- Price$434
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7589
- Product description(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate
- Packaging50mg
- Price$1396
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008143
- Product descriptionPF-04929113 95.00%
- Packaging5MG
- Price$501.11
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008143
- Product descriptionPF-04929113 95.00%
- Packaging10MG
- Price$644.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4065
- Product descriptionPF-04929113(SNX-5422)
- Packaging50mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4065
- Product descriptionPF-04929113 (SNX-5422)
- Packaging100mg
- Price$779
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4065
- Product descriptionPF-04929113 (SNX-5422)
- Packaging50mg
- Price$455
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4065
- Product descriptionPF-04929113 (SNX-5422)
- Packaging10mg
- Price$145
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98% | 1mg | $10 | 2026-05-28 | Buy |
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98% | 5mg | $19 | 2026-05-28 | Buy |
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98% | 10mg | $34 | 2026-05-28 | Buy |
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98% | 25mg | $74 | 2026-05-28 | Buy |
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate ≥98% | 50mg | $132 | 2026-05-28 | Buy |
| aablocks | AA00H0R3 | trans-4-([2-(Aminocarbonyl)-5-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl] phenyl]amino)cyclohexyl glycinate 98% | 1g | $2197 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228761 | PF04929113 97.00% | 25MG | $145 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228761 | PF04929113 97.00% | 100MG | $435 | 2026-05-27 | Buy |
| AK Scientific | X7589 | (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate | 10mg | $434 | 2021-12-16 | Buy |
| AK Scientific | X7589 | (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-aminoacetate | 50mg | $1396 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008143 | PF-04929113 95.00% | 5MG | $501.11 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008143 | PF-04929113 95.00% | 10MG | $644.7 | 2021-12-16 | Buy |
| ApexBio Technology | A4065 | PF-04929113(SNX-5422) | 50mg | $690 | 2021-12-16 | Buy |
| ApexBio Technology | A4065 | PF-04929113 (SNX-5422) | 100mg | $779 | 2026-05-06 | Buy |
| ApexBio Technology | A4065 | PF-04929113 (SNX-5422) | 50mg | $455 | 2026-05-06 | Buy |
| ApexBio Technology | A4065 | PF-04929113 (SNX-5422) | 10mg | $145 | 2026-05-06 | Buy |
Properties
Melting point :298-299℃
Boiling point :646.5±55.0 °C(Predicted)
Density :1.48
storage temp. :Store at -20°C
solubility :≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form :solid
pka :15.07±0.50(Predicted)
color :White to off-white
Boiling point :646.5±55.0 °C(Predicted)
Density :1.48
storage temp. :Store at -20°C
solubility :≥23.85 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form :solid
pka :15.07±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112), which binds both Hsp90α and Hsp90β with an IC50 value of 30 nM. The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration. The active inhibitor causes degradation of Hsp90 client proteins, including HER2, and reduces phosphorylation of downstream kinases, including Akt and ERK1/2, leading to apoptosis in cancer cells. Oral administration of the prodrug, PF-04929113, reduces tumor growth and prolongs survival in mouse models of multiple myeloma and prostate cancer.More related product prices
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