LDE-225 Diphosphate
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- $32 - $1802
- Product name: LDE-225 Diphosphate
- CAS: 1218778-77-8
- MF: C26H32F3N3O11P2
- MW: 681.4885116
- EINECS:
- MDL Number:MFCD16627994
- Synonyms:LDE225 Diphosphate, >=98%;Erismodegib Diphosphate, NVP-LDE225 (diphosphate salt);ErisModegib Diphosphate;LDE 225 Diphosphate;LDE225 (Diphosphate);LDE-225 Diphosphate;NVP-LDE 225 Diphosphate;LDE 225 phosphate
73 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250MG
- 500mg
- 1000mg
- 10mM(in1mLDMSO)
- 1G
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)
- Packaging5mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)
- Packaging10mg
- Price$62
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)
- Packaging25mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)
- Packaging50mg
- Price$113
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009C9U
- Product descriptionrel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)
- Packaging100mg
- Price$179
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging100MG
- Price$325
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging100MG
- Price$325
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging250MG
- Price$650
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging250MG
- Price$650
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging1G
- Price$1690
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT101926
- Product descriptionN-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98%
- Packaging1G
- Price$1690
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5720
- Product descriptionNVP-LDE225Diphosphatesalt
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging10MG
- Price$1027.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging5MG
- Price$903.33
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001229
- Product descriptionNVP-LDE225 DIPHOSPHATE 95.00%
- Packaging1MG
- Price$699.76
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) ≥98% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) | 5mg | $55 | 2026-05-28 | Buy |
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) | 10mg | $62 | 2026-05-28 | Buy |
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) | 25mg | $87 | 2026-05-28 | Buy |
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) | 50mg | $113 | 2026-05-28 | Buy |
| aablocks | AA009C9U | rel-N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate) | 100mg | $179 | 2026-05-28 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 100MG | $325 | 2026-05-25 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 100MG | $325 | 2026-05-27 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 250MG | $650 | 2026-05-25 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 250MG | $650 | 2026-05-27 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 1G | $1690 | 2026-05-25 | Buy |
| ACHEMBLOCK | T101926 | N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide bis(phosphate) 98% | 1G | $1690 | 2026-05-27 | Buy |
| AK Scientific | SYN5720 | NVP-LDE225Diphosphatesalt | 10mg | $160 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 10MG | $1027.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 5MG | $903.33 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001229 | NVP-LDE225 DIPHOSPHATE 95.00% | 1MG | $699.76 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :≥27.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
color :White to off-white
InChIKey :RWIVSVMMGFFZIJ-VWDRLOGHNA-N
SMILES :N1(C[C@H](C)O[C@H](C)C1)C1=CC=C(C=N1)NC(=O)C1C=CC=C(C2C=CC(=CC=2)OC(F)(F)F)C=1C.P(O)(O)(O)=O.P(O)(O)(O)=O |&1:2,5,r|
solubility :≥27.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
color :White to off-white
InChIKey :RWIVSVMMGFFZIJ-VWDRLOGHNA-N
SMILES :N1(C[C@H](C)O[C@H](C)C1)C1=CC=C(C=N1)NC(=O)C1C=CC=C(C2C=CC(=CC=2)OC(F)(F)F)C=1C.P(O)(O)(O)=O.P(O)(O)(O)=O |&1:2,5,r|
Safety Information
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Description
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of the GPCR-like receptor, Smoothened (SMO). In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers. LDE225 is an Hh signaling pathway inhibitor that acts by antagonizing SMO (IC50s = 1.3 and 2.5 nM for mouse and human, respectively). A dose of 20 mg/kg/day LDE225 has been shown to penetrate the blood brain barrier, inhibit Gli1 mRNA expression, and prevent tumor growth in a medulloblastoma allograft mouse model. This compound has been investigated in phase II clinical trials for potential treatment of several Hh pathway activated cancers.Related product price
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