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ChemicalBook >> CAS DataBase List >> LY3214996

LY3214996

$43 - $2600
Product name: LY3214996
CAS: 1951483-29-6
MF: C22H27N7O2S
MW: 453.56
EINECS:-0
MDL Number:MFCD31544324
Synonyms:LY3214996;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;CS-2495;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-;Temuterkib (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;LY-3214996 (LY3214996);Temuterkib, 10 mM in DMSO

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aablocks
ACHEMBLOCK
AK Scientific
Apolloscientific
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
DC Chemicals

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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging1mg
Price$43
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one
Packaging2mg
Price$78
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging5mg
Price$87
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging25mg
Price$201
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging10mg
Price$131
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging50mg
Price$382
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZC
Product description5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%
Packaging100mg
Price$573
Updated2026-05-30
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging25MG
Price$440
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging25MG
Price$440
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging100MG
Price$945
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging100MG
Price$945
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging5MG
Price$125
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberT97259
Product description6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%
Packaging5MG
Price$125
Updated2026-05-27
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ManufacturerAK Scientific
Product number5975EG
Product descriptionCID121408882
Packaging5mg
Price$357
Updated2021-12-16
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ManufacturerApolloscientific
Product numberBISN0168
Product descriptionLY3214996
Packaging1mg
Price$52
Updated2026-06-04
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ManufacturerBiorbyt Ltd
Product numberorb1225789
Product descriptionLY-3214996 >98%(HPLC)
Packaging10mg
Price$280
Updated2026-05-06
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	1mg	$43	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one	2mg	$78	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	5mg	$87	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	25mg	$201	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one 98%	10mg	$131	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	50mg	$382	2026-05-30	Buy
aablocks	AA01EAZC	5,6-Dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one ≥98%	100mg	$573	2026-05-30	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	25MG	$440	2026-05-25	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	25MG	$440	2026-05-27	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	100MG	$945	2026-05-25	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	100MG	$945	2026-05-27	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	5MG	$125	2026-05-25	Buy
ACHEMBLOCK	T97259	6,6-dimethyl-2-(2-(1-methyl-1H-pyrazol-5-ylamino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one 98%	5MG	$125	2026-05-27	Buy
AK Scientific	5975EG	CID121408882	5mg	$357	2021-12-16	Buy
Apolloscientific	BISN0168	LY3214996	1mg	$52	2026-06-04	Buy
Biorbyt Ltd	orb1225789	LY-3214996 >98%(HPLC)	10mg	$280	2026-05-06	Buy

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Properties

Boiling point :711.5±70.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) form :A crystalline solid
pka :6.58±0.10(Predicted)
color :White to yellow
InChI :InChI=1S/C22H27N7O2S/c1-22(2)19-15(20(30)29(22)9-8-28-10-12-31-13-11-28)14-17(32-19)16-4-6-23-21(25-16)26-18-5-7-24-27(18)3/h4-7,14H,8-13H2,1-3H3,(H,23,25,26)
InChIKey :JNPRPMBJODOFEC-UHFFFAOYSA-N
SMILES :N1(CCN2CCOCC2)C(=O)C2C=C(C3C=CN=C(NC4N(C)N=CC=4)N=3)SC=2C1(C)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC₅₀ = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

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LY3214996

Properties

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Description

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