PP2
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- $9 - $5040
- Product name: PP2
- CAS: 172889-27-9
- MF: C15H16ClN5
- MW: 301.77
- EINECS:
- MDL Number:MFCD01568210
- Synonyms:[1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]amine;1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine;PP2(AG 1879);AGL 1879;PP 2 (enzyme inhibitor);Src kinase inhibitor PP2;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-;AG 1879,AGL 1879
88 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
- Usbiological
Package
- 10mM(in1mLDMSO)
- 1mg
- 10mg
- 5mg
- 10mM*1mLinDMSO
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 50.00g
- 100.00g
- 250.00g
- Manufactureraablocks
- Product numberAA00AOXT
- Product descriptionSrc kinase inhibitor PP2 ≥98%
- Packaging5mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AOXT
- Product descriptionSrc kinase inhibitor PP2 ≥98%
- Packaging25mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AOXT
- Product descriptionSrc kinase inhibitor PP2 98%
- Packaging50mg
- Price$69
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00AOXT
- Product descriptionSrc kinase inhibitor PP2 ≥98%
- Packaging100mg
- Price$118
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX217640
- Product descriptionPP2 (AG 1879) 98%
- Packaging50MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX217640
- Product descriptionPP2 (AG 1879) 98%
- Packaging100MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3563-M005
- Product descriptionPP2 ≥98%(HPLC)
- Packaging5mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3563-M001
- Product descriptionPP2 ≥98%(HPLC)
- Packaging1mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3563-M001
- Product descriptionPP2 ≥98%(HPLC)
- Packaging1mg
- Price$35
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number8913AA
- Product description1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Packaging25mg
- Price$479
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging250mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging1mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging5mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging10mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging50mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA146866
- Product descriptionPP2 98+%
- Packaging100mg
- Price$107
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00AOXT | Src kinase inhibitor PP2 ≥98% | 5mg | $11 | 2026-05-28 | Buy |
| aablocks | AA00AOXT | Src kinase inhibitor PP2 ≥98% | 25mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00AOXT | Src kinase inhibitor PP2 98% | 50mg | $69 | 2026-05-28 | Buy |
| aablocks | AA00AOXT | Src kinase inhibitor PP2 ≥98% | 100mg | $118 | 2026-05-28 | Buy |
| ACHEMBLOCK | X217640 | PP2 (AG 1879) 98% | 50MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | X217640 | PP2 (AG 1879) 98% | 100MG | $150 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3563-M005 | PP2 ≥98%(HPLC) | 5mg | $80 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3563-M001 | PP2 ≥98%(HPLC) | 1mg | $40 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3563-M001 | PP2 ≥98%(HPLC) | 1mg | $35 | 2026-05-06 | Buy |
| AK Scientific | 8913AA | 1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 25mg | $479 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 250mg | $179 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 1mg | $9 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 5mg | $20 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 10mg | $29 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 50mg | $72 | 2021-12-16 | Buy |
| Ambeed | A146866 | PP2 98+% | 100mg | $107 | 2021-12-16 | Buy |
Properties
Boiling point :493.5±40.0 °C(Predicted)
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
pka :3.96±0.30(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChIKey :PBBRWFOVCUAONR-UHFFFAOYSA-N
SMILES :C1=NC(N)=C2C(C3=CC=C(Cl)C=C3)=NN(C(C)(C)C)C2=N1
Density :1.35±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
pka :3.96±0.30(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChIKey :PBBRWFOVCUAONR-UHFFFAOYSA-N
SMILES :C1=NC(N)=C2C(C3=CC=C(Cl)C=C3)=NN(C(C)(C)C)C2=N1
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. PP2 is a potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. It inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). PP2 does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 μM), or ZAP-70 (IC50 > 100 μM). PP2 inhibits the activation of focal adhesion kinase as well as its phosphorylation at Tyr577. PP2 also inhibits anti-CD3-stimulated tyrosine phosphorylation of human T-cells with an IC50 value of 600 nM.More related product prices
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