RETAPAMULIN
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- $5 - $1912
- Product name: RETAPAMULIN
- CAS: 224452-66-8
- MF: C30H47NO4S
- MW: 517.76
- EINECS:639-491-7
- MDL Number:MFCD11045316
- Synonyms:RETAPAMULIN;RetapaMulin (SB-275833);(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetraMethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester;RetapaMulin API;tetapaMulin;(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetraMethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate;Rebapamulin;SB-275833
61 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- Usbiological
Package
- 100mg
- 10mM(in1mLDMSO)
- 1mg
- 250.00mg
- 500mg
- 1.00g
- 2g
- 5.00g
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 1g
- 5g
- 10G
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97%
- Packaging5mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97%
- Packaging10mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester ≥99%
- Packaging50mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97%
- Packaging250mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97%
- Packaging1g
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039HR
- Product descriptionAcetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 98%
- Packaging5g
- Price$307
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228850
- Product descriptionRetapamulin 97.00%
- Packaging5G
- Price$290
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228850
- Product descriptionRetapamulin 97.00%
- Packaging1G
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberJ10910
- Product descriptionRetapamulin
- Packaging10mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ99900
- Product descriptionRetapamulin 95%
- Packaging1g
- Price$86
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberB719
- Product descriptionRetapamulin 98%(HPLC)
- Packaging1g
- Price$110
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ10910
- Product descriptionRetapamulin >98%(HPLC),powder
- Packaging50mg
- Price$138
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ99900
- Product descriptionRetapamulin 95%
- Packaging250mg
- Price$30
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberB719
- Product descriptionRetapamulin 98%(HPLC)
- Packaging250mg
- Price$40
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ10910
- Product descriptionRetapamulin >98%(HPLC),powder
- Packaging10mg
- Price$46
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ10910
- Product descriptionRetapamulin >98%(HPLC),powder
- Packaging5mg
- Price$27
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97% | 5mg | $16 | 2026-05-28 | Buy |
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97% | 10mg | $19 | 2026-05-28 | Buy |
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester ≥99% | 50mg | $20 | 2026-05-28 | Buy |
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97% | 250mg | $32 | 2026-05-28 | Buy |
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 97% | 1g | $68 | 2026-05-28 | Buy |
| aablocks | AA0039HR | Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester 98% | 5g | $307 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228850 | Retapamulin 97.00% | 5G | $290 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228850 | Retapamulin 97.00% | 1G | $95 | 2026-05-27 | Buy |
| AK Scientific | J10910 | Retapamulin | 10mg | $96 | 2021-12-16 | Buy |
| AK Scientific | J99900 | Retapamulin 95% | 1g | $86 | 2026-06-04 | Buy |
| AK Scientific | B719 | Retapamulin 98%(HPLC) | 1g | $110 | 2026-06-04 | Buy |
| AK Scientific | J10910 | Retapamulin >98%(HPLC),powder | 50mg | $138 | 2026-06-04 | Buy |
| AK Scientific | J99900 | Retapamulin 95% | 250mg | $30 | 2026-06-04 | Buy |
| AK Scientific | B719 | Retapamulin 98%(HPLC) | 250mg | $40 | 2026-06-04 | Buy |
| AK Scientific | J10910 | Retapamulin >98%(HPLC),powder | 10mg | $46 | 2026-06-04 | Buy |
| AK Scientific | J10910 | Retapamulin >98%(HPLC),powder | 5mg | $27 | 2026-06-04 | Buy |
Properties
Boiling point :594.9±50.0 °C(Predicted)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥114.8 mg/mL in EtOH; ≥16.15 mg/mL in DMSO
form :solid
pka :14.65±0.70(Predicted)
color :White to off-white
InChIKey :STZYTFJPGGDRJD-IFPFAXJDNA-N
SMILES :S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
CAS DataBase Reference :224452-66-8(CAS DataBase Reference)
Density :1.16±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in H2O; ≥114.8 mg/mL in EtOH; ≥16.15 mg/mL in DMSO
form :solid
pka :14.65±0.70(Predicted)
color :White to off-white
InChIKey :STZYTFJPGGDRJD-IFPFAXJDNA-N
SMILES :S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
CAS DataBase Reference :224452-66-8(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Antibacterial retapamulin is a derivative of the natural product pleuromutilin and was developed by Glaxo and approved in the US in 2007 for the treatment of skin infections. It has a unique mechanism of action, inhibiting bacterial protein synthesis by inhibiting the larger subunit of the ribosome, and thus has no cross resistance to other antibacterial agents. Pleuromutilin is a tricyclic diterpenoid that was first isolated in 1951 from the edible mushroom Pleurotus mutilus. The first semisynthetic analogs tiamulin and valnemulin, developed for veterinary use, have been shown to interact uniquely with bacterial ribosomes by high affinity binding to a site on the 50S subunit. Binding to this site interferes with ribosomal peptidyl transferase activity, blocks P-site interactions, and prevents the evolution of active 50S ribosomal subunits. Retapamulin, the first pleuromutilin approved for human use, behaves similarly to selectively inhibit bacterial protein synthesis. This novel mechanism of action has been implicated in the lack of in vitro target-specific cross-resistance with other classes of antibiotics.More related product prices
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Suppliers and manufacturers
Beijing Mediking Biopharm Co., Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Shanghai Arbor Chemical Co., Ltd.
Xiamen AmoyChem Co., Ltd
Changzhou Ditong Chemical Co.,Ltd
BOC Sciences
Retapamulin
CAS:224452-66-8
