SD-208
|
- $9 - $1872
- Product name: SD-208
- CAS: 627536-09-8
- MF: C17H10ClFN6
- MW: 352.75
- EINECS:
- MDL Number:MFCD09038685
- Synonyms:SD-208;2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE;2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine;2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine;4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-;2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine;SCI 208;2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
82 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10
- 2MG
- 10mM*1mLinDMSO
- 50
- 5mg
- 10mg
- 25mg
- 50mg
- 50.00mg
- 100.00mg
- 100mg
- 250mg
- 250.00mg
- 1G
- Manufactureraablocks
- Product numberAA00ECBV
- Product descriptionSD-208 ≥98%
- Packaging5mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBV
- Product descriptionSD-208 ≥98%
- Packaging25mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBV
- Product descriptionSD-208 99%
- Packaging50mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBV
- Product descriptionSD-208 99%
- Packaging100mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBV
- Product descriptionSD-208 99%
- Packaging250mg
- Price$145
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22534
- Product descriptionSD208 98%
- Packaging100MG
- Price$140
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22534
- Product descriptionSD208 98%
- Packaging1G
- Price$665
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4032AH
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
- Packaging5mg
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging100mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging50mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging1mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging5mg
- Price$19
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging10mg
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging250mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150813
- Product description2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+%
- Packaging1g
- Price$423
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000302
- Product descriptionSD-208 95.00%
- Packaging2MG
- Price$185
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ECBV | SD-208 ≥98% | 5mg | $10 | 2026-05-28 | Buy |
| aablocks | AA00ECBV | SD-208 ≥98% | 25mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00ECBV | SD-208 99% | 50mg | $68 | 2026-05-28 | Buy |
| aablocks | AA00ECBV | SD-208 99% | 100mg | $92 | 2026-05-28 | Buy |
| aablocks | AA00ECBV | SD-208 99% | 250mg | $145 | 2026-05-28 | Buy |
| ACHEMBLOCK | M22534 | SD208 98% | 100MG | $140 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22534 | SD208 98% | 1G | $665 | 2026-05-27 | Buy |
| AK Scientific | 4032AH | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine | 5mg | $146 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 100mg | $105 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 50mg | $70 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 1mg | $9 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 5mg | $19 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 10mg | $28 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 250mg | $166 | 2021-12-16 | Buy |
| Ambeed | A150813 | 2-(5-Chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine 98+% | 1g | $423 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000302 | SD-208 95.00% | 2MG | $185 | 2021-12-16 | Buy |
Properties
Boiling point :460.4±45.0 °C(Predicted)
Density :1.487
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :4.56±0.26(Predicted)
form :powder
color :off-white to tan
InChI :1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChIKey :BERLXWPRSBJFHO-UHFFFAOYSA-N
SMILES :Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
Density :1.487
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :4.56±0.26(Predicted)
form :powder
color :off-white to tan
InChI :1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChIKey :BERLXWPRSBJFHO-UHFFFAOYSA-N
SMILES :Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
TGF-β is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies. TGF-β signals through two receptor tyrosine kinases, TGF-βRI and TGF-βRII. SD 208 is a potent inhibitor of TGF-βRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of other tyrosine or serine/threonine kinases, including TGF-βRII kinase. It blocks both autocrine and paracrine TGF-β signaling in glioma cells, inhibiting TGF-β-induced migration and invasion without affecting viability or proliferation. SD 208 is orally bioavailable and prevents TGF-β-induced Smad phosphorylation in spleens and brains of mice. It improves survival in mice with xenografted glioma by heightening the immune response against tumor cells and reverses bronchial hyperresponsiveness to allergens in ovalbumin-exposed mice. SD 208 also suppresses TGF-β-induced differentiation of proliferating myofibroblasts and induces dedifferentiation in the absence of TGF-β.More related product prices
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