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ChemicalBook >> CAS DataBase List >> SGI-1776

SGI-1776

$5 - $3791
Product name: SGI-1776
CAS: 1025065-69-3
MF: C20H22F3N5O
MW: 405.42
EINECS:200-258-5
MDL Number:MFCD16659064
Synonyms:N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776;SGI-1776;SGI-1776 free base;N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776, >=98%;SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine;SGI-1776 FREE BASE;SGI1776

Price86 Properties Safety Information Description

86 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Synthonix
TRC
Usbiological

Package

50.00mg
10mM(1mLinDMSO)
1unit
EvaluationSample
100.00mg
250.00mg
10mM*1mLinDMSO
1000mg
1g
1mg
10mM(in1mLDMSO)
5mg
10mg
25mg
50mg
100mg
250mg
10mM(in 1mL DMSO)

Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 98%
Packaging1mg
Price$5
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging5mg
Price$16
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging10mg
Price$23
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging50mg
Price$57
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging25mg
Price$35
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging100mg
Price$95
Updated2026-05-25
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Manufactureraablocks
Product numberAA0007J1
Product descriptionSGI-1776 99+%
Packaging250mg
Price$161
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging250MG
Price$240
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging250MG
Price$240
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging25MG
Price$45
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging25MG
Price$45
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging100MG
Price$99
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberQ65806
Product descriptionN-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%
Packaging100MG
Price$99
Updated2026-05-27
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1193-M001
Product descriptionSGI-1776 ≥95%
Packaging1mg
Price$86
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1193-M001
Product descriptionSGI-1776 ≥95%
Packaging1mg
Price$86
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1193-M005
Product descriptionSGI-1776 ≥95%
Packaging5mg
Price$140
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0007J1	SGI-1776 98%	1mg	$5	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	5mg	$16	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	10mg	$23	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	50mg	$57	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	25mg	$35	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	100mg	$95	2026-05-25	Buy
aablocks	AA0007J1	SGI-1776 99+%	250mg	$161	2026-05-25	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	250MG	$240	2026-05-25	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	250MG	$240	2026-05-27	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	25MG	$45	2026-05-25	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	25MG	$45	2026-05-27	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	100MG	$99	2026-05-25	Buy
ACHEMBLOCK	Q65806	N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine 98%	100MG	$99	2026-05-27	Buy
Adipogen Life Sciences	SYN-1193-M001	SGI-1776 ≥95%	1mg	$86	2021-12-16	Buy
Adipogen Life Sciences	SYN-1193-M001	SGI-1776 ≥95%	1mg	$86	2026-05-06	Buy
Adipogen Life Sciences	SYN-1193-M005	SGI-1776 ≥95%	5mg	$140	2026-05-06	Buy

Next Last

Properties

Density :1.37
storage temp. :Store at -20°C
solubility :≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH
pka :9.22±0.10(Predicted)
form :Solid
color :White to yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

The Pim family proteins are serine/threonine kinases involved in cancer progression. SGI-1776 is a potent inhibitor of all three human Pim kinases (IC50s = 7, 363, and 69 nM for Pim-1, Pim-2, and Pim-3, respectively). While it also inhibits FLT3 and haspin (IC50s = 44 and 34 nM, respectively), SGI-1776 has little effect on several other kinases, including cell cycle kinases. SGI-1776 induces apoptosis in lymphocytes from patients with chronic or acute lymphocytic leukemia but not in those from healthy donors. At 10 μM, it reduces STAT3 phosphorylation without reducing STAT3 expression in cancer cells, and this correlates with inhibition of cell proliferation. SGI-1776 also enhances the activity of sunitinib against renal cell carcinoma and resensitizes chemoresistant prostate cancer cells to taxanes.

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Suppliers and manufacturers

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SGI-1776

Properties

Safety Information

Description

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