Tepotinib
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- $35 - $3772
- Product name: Tepotinib
- CAS: 1100598-32-0
- MF: C29H28N6O2
- MW: 492.57
- EINECS:
- MDL Number:MFCD18452823
- Synonyms:Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl];3-(1-(3-(5-((1-Methylpiperidin-4-yl)Methoxy)pyriMidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile;3-(1-(3-(5-((1-METHYLPIPERIDIN-4-YL)METHOXY)PYRIMIDIN-2-YL)BENZYL)-1,6-DIHYDRO-6-OXOPYRIDAZIN-3-YL)B;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile;Tepotinib (EMD 1214063);MSC2156119;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile EMD-1214063;EMD-1214063 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile
57 prices
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Brand
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
Package
- 10mM(1mLinDMSO)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 10.00mg
- 50.00mg
- 100.00mg
- 250mg
- 1000mg
- 10mM(in 1mL DMSO)
- 5MG
- 10mg
- 25MG
- 50mg
- 100MG
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging5MG
- Price$55
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging5MG
- Price$55
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging100MG
- Price$450
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging100MG
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging1G
- Price$1850
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging25MG
- Price$175
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging25MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22536
- Product descriptionEMD1214063 98%
- Packaging1G
- Price$1850
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002572
- Product descriptionEMD-1214063 95.00%
- Packaging5MG
- Price$300.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mM(in 1mL DMSO)
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging5mg
- Price$126
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14721
- Product descriptionTepotinib 99.94%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$136
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | M22536 | EMD1214063 98% | 5MG | $55 | 2026-05-25 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 5MG | $55 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 100MG | $450 | 2026-05-25 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 100MG | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 1G | $1850 | 2026-05-25 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 25MG | $175 | 2026-05-25 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 25MG | $175 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22536 | EMD1214063 98% | 1G | $1850 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | KIN0002572 | EMD-1214063 95.00% | 5MG | $300.3 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 50mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 100mg | $700 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mM(in 1mL DMSO) | $138 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mg | $155 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 5mg | $105 | 2021-12-16 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 5mg | $126 | 2026-05-26 | Buy |
| Arctom | HY-14721 | Tepotinib 99.94% | 10mM*1mLinDMSO(Solid+Solvent) | $136 | 2026-05-26 | Buy |
Properties
Boiling point :626.5±65.0 °C(Predicted)
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Appearance :white solid
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Appearance :white solid
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases. It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models.More related product prices
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Suppliers and manufacturers
Moxin Chemicals
Suzhou ARTK Medchem Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Suzhou Ryan Pharmachem Technology Co.,Ltd.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Shenzhen Shengda Pharma Limited
Tepotinib Impurity
CAS:1100598-32-0
![Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]](https://img.chemicalbook.com/ProductImageEN/2019-12/small/c8e99c4c-c412-4599-8b63-00e0c8736d86.jpg){kind=small}
