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ChemicalBook >> CAS DataBase List >> U 18666A

U 18666A

U 18666A price.
  • $44 - $2600
  • Product name: U 18666A
  • CAS: 3039-71-2
  • MF: C25H42ClNO2
  • MW: 424.06
  • EINECS:
  • MDL Number:MFCD00210908
  • Synonyms:U 18666A;3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL;3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL;3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE;(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE;(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE;U18666A,HCl;(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
77 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Thermo Scientific Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 2mg
  • 10
  • 10mM(1mLinDMSO)
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250MG
  • 1g
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging2mg
  • Price$50
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride ≥95%
  • Packaging5mg
  • Price$53
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging10mg
  • Price$95
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging25mg
  • Price$168
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging1mg
  • Price$44
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging50mg
  • Price$261
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002ZW1
  • Product description3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
  • Packaging100mg
  • Price$383
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberZ238358
  • Product descriptionU18666A 98%
  • Packaging100MG
  • Price$540
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberZ238358
  • Product descriptionU18666A 98%
  • Packaging250MG
  • Price$1080
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberZ238358
  • Product descriptionU18666A 98%
  • Packaging25MG
  • Price$220
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number4494CR
  • Product description3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride
  • Packaging10mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6812
  • Product descriptionU 18666A
  • Packaging10mg
  • Price$149
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6812
  • Product descriptionU18666A
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6812
  • Product descriptionU18666A
  • Packaging50mg
  • Price$422
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6812
  • Product descriptionU 18666A
  • Packaging50mg
  • Price$447
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6812
  • Product descriptionU 18666A
  • Packaging25mg
  • Price$261
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 2mg $50 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride ≥95% 5mg $53 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 10mg $95 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 25mg $168 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 1mg $44 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 50mg $261 2026-05-28 Buy
aablocks AA002ZW1 3β-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride 100mg $383 2026-05-28 Buy
ACHEMBLOCK Z238358 U18666A 98% 100MG $540 2026-05-27 Buy
ACHEMBLOCK Z238358 U18666A 98% 250MG $1080 2026-05-27 Buy
ACHEMBLOCK Z238358 U18666A 98% 25MG $220 2026-05-27 Buy
AK Scientific 4494CR 3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride 10mg $197 2021-12-16 Buy
ApexBio Technology B6812 U 18666A 10mg $149 2026-05-06 Buy
ApexBio Technology B6812 U18666A 10mg $100 2021-12-16 Buy
ApexBio Technology B6812 U18666A 50mg $422 2021-12-16 Buy
ApexBio Technology B6812 U 18666A 50mg $447 2026-05-06 Buy
ApexBio Technology B6812 U 18666A 25mg $261 2026-05-06 Buy

Properties

Melting point :195-196.5 °C(lit.)
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
InChI :1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChIKey :ICPRVJHNLABCSA-UHFFFAOYSA-N
SMILES :[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.

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