2730-71-4
中文名稱
硫代秋水仙堿
英文名稱
thiocolchicine
CAS
2730-71-4
分子式
C22H25NO5S
分子量
415.5
MOL 文件
2730-71-4.mol
更新日期
2023/03/20 15:41:27
2730-71-4 結(jié)構(gòu)式
基本信息
中文別名
硫秋水仙堿硫代秋水仙堿
英文別名
NSC 186301thiocolchicine
thiocholchicine
10-Thiocolchicine
Thiocolchicoside EP Impurity B
10-Demethoxy-10-methylthiocolchicine
(S)-7-Acetylamino-6,7-dihydro-10-methylthio-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one
(S)-7α-Acetylamino-6,7-dihydro-10-(methylthio)-1,2,3-trimethoxybenzo[a]heptalene-9(5H)-one
N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-methylthio-9-oxobenzo[a]heptalen-7-yl]acetamide
(S)-N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
物理化學(xué)性質(zhì)
熔點(diǎn)193℃
比旋光度D20 -221°
沸點(diǎn)729.1±60.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲存條件-20°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系數(shù)(pKa)14.75±0.40(Predicted)
形態(tài)粉末
顏色白色至米色
InChI1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChIKeyCMEGANPVAXDBPL-INIZCTEOSA-N
SMILESS(C)c1[c](cc2c(cc1)c3c(cc(c(c3OC)OC)OC)CC[C@@H]2NC(=O)C)=O
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H300+H330-H318-H340
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說明26
危險(xiǎn)品運(yùn)輸編號UN 1544PSN1 6.1 / PGI
WGK Germany3
REACH 注冊登記Active
存儲類別6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
very toxic hazardous materials
危險(xiǎn)性類別Acute Tox. 1 Inhalation
Acute Tox. 2 Oral
Eye Dam. 1
Muta. 1B
Acute Tox. 2 Oral
Eye Dam. 1
Muta. 1B
硫代秋水仙堿價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-116852 | 硫代秋水仙堿 Thiocolchicine | 2730-71-4 | 5 mg | 500元 |
| 2025/12/22 | HY-116852 | 硫代秋水仙堿 Thiocolchicine | 2730-71-4 | 10 mg | 800元 |
| 2025/12/22 | HY-116852 | 硫代秋水仙堿 Thiocolchicine | 2730-71-4 | 25 mg | 1600元 |
常見問題列表
生物活性
Thiocolchicine 是秋水仙堿 (HY-16569) 的衍生物，是一種有效的微管蛋白聚合 (tubulin polymerization) 抑制劑 (IC50=2.5 μM)，競爭性結(jié)合微管蛋白 (Ki=0.7 μM)。Thiocolchicine 可以作為 ADC 的毒素分子。體外研究
Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC 50 values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively.Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. It inhibits cell proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells with IC 50 s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells (IC 50 =50 nM).