1-(2-Bromoethoxy)-4-nitrobenzene synthesis
- Product Name:1-(2-Bromoethoxy)-4-nitrobenzene
- CAS Number:13288-06-7
- Molecular formula:C8H8BrNO3
- Molecular Weight:246.06
Yield: 81%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80;
Steps:
2.1 Step 1. Synthesis of compound VI-1
Take the commercially available compound V-1 (1.4g, 10mmol), 1,2-dibromoethane (2.3g, 12mmol), K2CO3 (2.8g, 20mmol) and add to DMF (30mL), heat and stir at 80°C Until TLC shows that the reaction is complete.After the reaction mixture was cooled to room temperature, it was poured into ice water (50 mL), stirred, and extracted with dichloromethane (20 mL×3). The extracted organic phases were combined, washed with water (50 mL×5), and dried over anhydrous sodium sulfate. The dried organic phase was evaporated on a rotary evaporator to remove the solvent, and the obtained residue was purified by column chromatography to obtain product VI-1, 2.0 g, with a yield of 81%.
References:
CN112920131, 2021, A Location in patent:Paragraph 0055-0059
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