1-(3,5-Dichlorophenyl)ethanol synthesis
- Product Name:1-(3,5-Dichlorophenyl)ethanol
- CAS Number:184970-30-7
- Molecular formula:C8H8Cl2O
- Molecular Weight:191.05
14401-72-0
153 suppliers
$9.00/1g
184970-30-7
15 suppliers
$99.00/1g
Yield:184970-30-7 100%
Reaction Conditions:
with sodium tetrahydroborate;ethanol for 0.0833333 h;
Steps:
(+/-)-l-(3,5-dichlorophenyl)ethan-l-ol
Toa solution of l -(3,5-dichlorophenyl)ethan-l-one (l .OOg, 5.29 mmol) in EtOH(10 mL) at room temperature was added solid NaB (100 mg, 2.64 mmol) in threeportions over 5 min with stirring. The solvent was evaporated and the resultantwhite solid treated with 1M HC1 (20 mL) and DCM (70 mL). The phases wereseparated and the organic phase was washed with brine (20 mL), dried (Na2S04),the mixture was filtered and the filtrate evaporated to dryness to afford(+/-)-l -(3,5-dichlorophenyl)ethan-l-ol as a cloudy oil (1025 mg, 100%) ; HNMR (250 MHz, CDC13) δ 1.47 (d, 3H), 4.85 (q, 1H), 7.24 - 7.28 (m,3H)
References:
WO2014/184234,2014,A1 Location in patent:Page/Page column 52
51-36-5
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$7.00/25g
917-54-4
178 suppliers
$52.10/25ml
14401-72-0
153 suppliers
$9.00/1g
184970-30-7
15 suppliers
$99.00/1g
917-64-6
147 suppliers
$45.00/10ml
10203-08-4
314 suppliers
$8.00/5g
184970-30-7
15 suppliers
$99.00/1g