1,3-Dibromo-2,2-dimethoxypropane synthesis
- Product Name:1,3-Dibromo-2,2-dimethoxypropane
- CAS Number:22094-18-4
- Molecular formula:C5H10Br2O2
- Molecular Weight:261.94
67-56-1
67-64-1
22094-18-4
Bromine (950 g, 5.9 mol) was slowly added dropwise to a stirred solution of compound 29.1 (157 g, 2.7 mol) in methanol (1.6 L) at 0 °C. After the dropwise addition, the reaction mixture was heated and stirred continuously for 15 hours. Upon completion of the reaction, the precipitate was collected by filtration and washed with cold methanol to give compound 29.2 (450 g, 60% yield) as a white solid.
Yield:22094-18-4 60%
Reaction Conditions:
with bromine at 0 - 20; for 15 h;
Steps:
29 1,3-dibromo-2,2-dimethoxypropane (29.2)
To a stirring solutionof compound 29.1(157g, 2.7 mol) in CH30H (1.6 L) at 0°Cwas added Br2 (950 g, 5.9 moL) dropwise, and the reactionwas stirred with warming tort for 15 hr. The precipitate was collected by filtration and was washed with cold methanol to yield5 compound29.2 (450 g, 60%) as a white solid.
References:
ACHAOGEN, INC.;LINSELL, Martin Sheringham;AGGEN, James Bradley;DOZZO, Paola;HILDEBRANDT, Darin James;COHEN, Frederick;KASAR, Ramesh Annasaheb;KANE, Timothy Robert;GLIEDT, Micah James;MCENROE, Glenn A. WO2014/165075, 2014, A1 Location in patent:Page/Page column 86; 87
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