1-BROMO-2,2-DIMETHOXYPROPANE synthesis
- Product Name:1-BROMO-2,2-DIMETHOXYPROPANE
- CAS Number:126-38-5
- Molecular formula:C5H11BrO2
- Molecular Weight:183.04
598-31-2
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$60.00/50mg
149-73-5
542 suppliers
$12.00/5g
126-38-5
146 suppliers
$12.00/1g
Yield:126-38-5 87.2%
Reaction Conditions:
with hydrogenchloride in methanol;water at 20; for 2 h;
Steps:
1.2-5.2
S2. Upper protection reaction: Dissolve 30 g of 1-bromoacetone in 13 mL of methanol at room temperature, add 26 g of trimethyl orthoformate and 5.2 g of concentrated hydrochloric acid in sequence, stir and react at room temperature for 2 hours, and TLC detects that the reaction is complete.Adjust the reaction solution to weakly alkaline with a small amount of triethylamine. After removing the trimethyl orthoformate by rotary evaporation, add cold sodium hydroxide methanol solution, extract with dichloromethane, and spin dry the solvent to obtain the product 1-bromo-2 , 2-Dimethoxypropane 35.76g, the yield was 89.2percent.
References:
Beijing Fu Baike Biological Co., Ltd.;Du Chimin CN111348992, 2020, A Location in patent:Page/Page column 4-6
67-56-1
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$7.29/5ml-f
77-76-9
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22094-18-4
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$5.00/1g
126-38-5
146 suppliers
$12.00/1g