1-(4'-Bromophenoxy)-1-ethoxyethane synthesis
- Product Name:1-(4'-Bromophenoxy)-1-ethoxyethane
- CAS Number:39255-20-4
- Molecular formula:C10H13BrO2
- Molecular Weight:245.11
Yield:39255-20-4 86%
Reaction Conditions:
with potassium carbonate in DMF (N,N-dimethyl-formamide) at 20; for 18 h;
Steps:
3.A Part A. Preparation of [1-BROMO-4- (2-ETHOXY-ETHOXY)-BENZENE] (2):
To a room temperature mixture [OF 4-BROMOPHENOL] (1) (5.0 g, 28.9 mmol) in 15 mL DMF was added potassium carbonate (4.4 g, 31.8 mmol) and 2-bromoethyl ethyl ether (5.5 g, 36.4 mmol). The resulting mixture was stirred for 18 hr at room temperature. Subsequently, no starting material (1) was detectable by HPLC. The solvent was removed, and the resulting mixture was diluted in 100 mL ethyl acetate and filtered. The filtrate was concentrated to produce 6.2 g [(86%] yield) of the desired compound (2) in the form of a yellow oil.
References:
WO2004/811,2003,A1 Location in patent:Page 124-125
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