1,4-DICHLORO-2-BUTANOL synthesis
- Product Name:1,4-DICHLORO-2-BUTANOL
- CAS Number:2419-74-1
- Molecular formula:C4H8Cl2O
- Molecular Weight:143.01
3068-00-6
286 suppliers
$10.00/5g
2419-74-1
55 suppliers
$45.00/100mg
Yield: 57.2%
Reaction Conditions:
with hydrogenchloride;acetic acid at 85 - 90;Reagent/catalyst;Temperature;
Steps:
1 (Example 1)
This embodiment is the intermediate 1,4-dichloro-2-butanol Preparation: In a 500mL four-necked flask was added 250g of 1,2,4-butanetriol and 7g of acetic acid, stirring and heated to 85 ; Then pass into the hydrogen chloride gas, and temperature 90 ± 2 , when a large number of hydrogen chloride gas overflow,Stop aeration, and cooled to room temperature (15 ~ 25 , the same below); followed by slow addition of aqueous sodium carbonate, the system pH was adjusted to 5.5 ± 0.1, standing stratification, the lower organic phase was washed with aqueous sodium chloride solution Distillation, collected 60 ~ 64 ° C distillate to obtain 193.0g colorless and transparent liquid 1,4-dichloro-2-butanol, a yield of 57.2%, a purity of 90.7%
References:
Changzhou Sunshine Pharmaceutical Co., Ltd.;Hu Jinping;Hu Guoyi;Zheng Jianlong;Xi Xiaojin CN106631956, 2017, A Location in patent:Paragraph 0019; 0020; 0021
16714-78-6
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$159.06/1gm:
2419-74-1
55 suppliers
$45.00/100mg
453-20-3
284 suppliers
$9.00/1g
2419-74-1
55 suppliers
$45.00/100mg