1-(4-NITROPHENYL)-3-METHYL-5-PYRAZOLONE synthesis
- Product Name:1-(4-NITROPHENYL)-3-METHYL-5-PYRAZOLONE
- CAS Number:6402-09-1
- Molecular formula:C10H9N3O3
- Molecular Weight:219.2
Yield: 64%
Reaction Conditions:
in ethanol
Steps:
1a
(cyclization reaction) 1.63 g of p-nitrophenylhydrazine hydrochloride and 1.26 g of ethyl acetoacetate are heated under reflux in 30 ml of ethanol for 45 min. The mixture is concentrated somewhat in vacuo. The crystals which have separated out are then filtered off with suction. Yield: 1.20 g of 5-methyl-2-(4-nitrophenyl)-2,4-dihydro-3-pyrazolone (64% of theory); Melting point: 223° C.
References:
Merck Patent Gesellschaft mit beschrankter Haftung US5869516, 1999, A
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