1-BROMO-2,4-DIMETHYL-5-NITROBENZENE synthesis
- Product Name:1-BROMO-2,4-DIMETHYL-5-NITROBENZENE
- CAS Number:69383-59-1
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
583-70-0
69383-59-1
General procedure for the synthesis of 5-bromo-2,4-dimethylnitrobenzene from 2,4-dimethylbromobenzene: 1-bromo-2,4-dimethylbenzene (9 g, 48.6 mmol) was slowly added to a 60% solution of nitric acid (100 mL) at room temperature. The reaction mixture was stirred continuously at room temperature overnight. Upon completion of the reaction, the mixture was carefully poured into ice water and extracted with ethyl acetate (EtOAc). After separation of the organic phase, it was dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to afford the crude product 1-bromo-2,4-dimethyl-5-nitrobenzene (6.5 g). The product can be used directly in the subsequent reaction steps without further purification.
2124-47-2
138 suppliers
$12.00/250mg
69383-59-1
103 suppliers
$5.00/250mg
Yield:-
Reaction Conditions:
Diazotization.man fuehrt die Diazoniumverbindung in das Diazopiperidid ueber und kocht dieses mit konz. Bromwasserstoffsaeure;
References:
Ahrens [Justus Liebigs Annalen der Chemie,1892,vol. 271,p. 17]
583-70-0
244 suppliers
$15.00/5mg
69383-59-1
103 suppliers
$5.00/250mg