2,4-Dimethylbromobenzene synthesis
- Product Name:2,4-Dimethylbromobenzene
- CAS Number:583-70-0
- Molecular formula:C8H9Br
- Molecular Weight:185.06
108-38-3
583-70-0
General procedure for the synthesis of 2,4-dimethylbromobenzene from m-xylene: N-bromosuccinimide (NBS, 1.0 mmol) and Catalyst 1 (gold loading of 0.1 or 1 mol% of the substrate) were accurately weighed and added to a 10 mL sealed reaction vessel, followed by 1,2-dichloroethane (DCE, 2 mL) and m-xylene (1.0 mmol). The reaction mixture was stirred at a set temperature for a specified time. After completion of the reaction, the catalyst was separated using a magnet and the reaction solution was concentrated under reduced pressure and purified by column chromatography.
108-38-3
382 suppliers
$10.60/50gm:
583-70-0
241 suppliers
$15.00/5mg
Yield:583-70-0 97%
Reaction Conditions:
with N-Bromosuccinimide in 1,2-dichloro-ethane at 60; for 10 h;Sealed tube;
Steps:
2.6 Typical procedure for the bromination
General procedure: NBS (1.0 mmol) and catalyst 1 (0.1 or 1 mol % Au based on the substrate) were weighted into a 10 mL sealed vessel, and then DCE (2 mL) and the substrate (1.0 mmol) were added. The reaction was stirred at the required temperature for the specified time. After reaction, the catalyst was removed with a magnet, and the solution was concentrated under reduced pressure and purified by column chromatography.
References:
Li, Bai;Gao, Linfeng;Bian, Fengling;Yu, Wei [Tetrahedron Letters,2013,vol. 54,# 9,p. 1063 - 1066] Location in patent:supporting information
108-38-3
382 suppliers
$10.60/50gm:
583-70-0
241 suppliers
$15.00/5mg
620-13-3
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$10.00/1g
611-01-8
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583-70-0
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$15.00/5mg
87241-52-9
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583-70-0
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95-68-1
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583-70-0
241 suppliers
$15.00/5mg