1-CHLORO-4-PHENYLBUTANE synthesis
- Product Name:1-CHLORO-4-PHENYLBUTANE
- CAS Number:4830-93-7
- Molecular formula:C10H13Cl
- Molecular Weight:168.66
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Yield: 98.6%
Reaction Conditions:
in tetrahydrofuran at 0 - 5; for 6 h;
Steps:
1 Example 1
Example 1 Benzylmagnesium chloride/tetrahydrofuran solution (content: 12.5% by weight) (150 g) was placed in a reaction vessel equipped with a stirrer and a condenser and the inner temperature was adjusted to 0°C. At the same temperature, 1-bromo-3-chloropropane (19.6 g) was added dropwise over 2 hours, followed by stirring and maintaining at the inner temperature of 0 to 5°C for 4 hours. The reaction mixture was added to 10% by weight hydrochloric acid (55 g) (at this time, the inner temperature of the mixture was maintained at 30°C or lower). After stirring and allowing to stand, an organic layer was separated and the organic layer was washed with saturated saline (55 g) and concentrated under reduced pressure to obtain an oily product (23.2 g) containing 1-chloro-4-phenylbutane. When this was analyzed by gas chromatography (Internal standard method), the content of 1-chloro-4-phenylbutane was 89.5% by weight. Yield based on l-bromo-3-chloropropane: 98.6%.
References:
SUMITOMO CHEMICAL COMPANY LIMITED;ONO PHARMACEUTICAL CO., LTD. EP1369405, 2003, A1 Location in patent:Page 4
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