1-phenylguanidine synthesis
- Product Name:1-phenylguanidine
- CAS Number:2002-16-6
- Molecular formula:C7H9N3
- Molecular Weight:135.17
Yield: 95%
Reaction Conditions:
with scandium tris(trifluoromethanesulfonate) in water at 100; for 12 h;Reagent/catalyst;
Steps:
General Procedure for the Guanylation of Amines:
General procedure: To a solution of p-methoxyaniline (1b, 61.6 mg, 0.50 μmol)and cyanamide (25.2 mg, 0.60 μmol) in H2O (2.5 mL) wasadded Sc(OTf)3 (24.6 mg, 50 nmol) at r.t. After the solutionwas stirred at 100 °C for 2 d, the resulting mixture waswashed with CHCl3 (3 × 10 mL). The aqueous layer wasconcentrated in vacuo, and the residue was purified by filtering through silica gel pad (CHCl3-MeOH, 20:1).
References:
Tsubokura, Kazuki;Iwata, Takayuki;Taichi, Misako;Kurbangalieva, Almira;Fukase, Koichi;Nakao, Yoichi;Tanaka, Katsunori [Synlett,2014,vol. 25,# 9,p. 1302 - 1306]
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1000210-73-0
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2002-16-6
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2002-16-6
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2002-16-6
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2002-16-6
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