1,2,3-TRIPHENYLGUANIDINE synthesis
- Product Name:1,2,3-TRIPHENYLGUANIDINE
- CAS Number:101-01-9
- Molecular formula:C19H17N3
- Molecular Weight:287.36
Yield: 78%
Reaction Conditions:
with triethylamine;1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in acetonitrile at 20;
Steps:
General experimental procedure for guanidines (entries 11-18)
General procedure: Method B: To a stirred solution of 1,3-disubstituted thiourea (5 mmol) and amine (5 mmol) in acetonitrile (10 mL) was added drop wise a solution of IBX (5.5 mmol), in triethylamine (15 mmol) at rt over a period of 10 min. After completion of reaction as analysed by TLC (reaction time 30 min) the mixture was extracted with (2 × 15 mL) ethyl acetate. The organic layer was washed with 10% aqueous sodium bicarbonate solution (2 × 15 mL), evaporated and chromatographed to afford the pure product.
References:
Dangate, Prasad S.;Akamanchi, Krishnacharya G. [Tetrahedron Letters,2012,vol. 53,# 50,p. 6765 - 6767]
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