1-Phenylpiperazine synthesis
- Product Name:1-Phenylpiperazine
- CAS Number:92-54-6
- Molecular formula:C10H14N2
- Molecular Weight:162.23
Yield:92-54-6 88%
Reaction Conditions:
with bis{1,1’-diphenyl-3,3’-methylenediimidazoline-2,2’-diylidene}nickel(II) dibromide;potassium tert-butylate in 1,4-dioxane at 90; for 4 h;Catalytic behavior;Inert atmosphere;Schlenk technique;Buchwald-Hartwig Coupling;Reagent/catalyst;
Steps:
5.4.1. General procedure for the Buchwald-Hartwig reaction
General procedure: Under an N2 atmosphere, KOtBu (1.3 mmol), complex 1 (1 mol %), dioxane (2 ml), amines (1.3 mmol) and aryl chlorides (1.0 mmol) were successively added into a Schlenk tube. The mixture was stirred vigorously at 90 °C for 4 h. Then the solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EA = 15:1) to give the pure products. The reported yields are the average of two runs.
References:
Nirmala, Muthukumaran;Saranya, Gandhi;Viswanathamurthi, Periasamy;Bertani, Roberta;Sgarbossa, Paolo;Malecki, Jan Grzegorz [Journal of Organometallic Chemistry,2017,vol. 831,p. 1 - 10] Location in patent:supporting information
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