Phenylboronic acid synthesis
- Product Name:Phenylboronic acid
- CAS Number:98-80-6
- Molecular formula:C6H7BO2
- Molecular Weight:121.93
Yield:98-80-6 99%
Reaction Conditions:
with cesium fluoride;Pd(dba)2 in toluene;
Steps:
4 Example 4
Example 4 This is an example of Pd/ligand 1-catalyzed Suzuki reaction for biaryl synthesis. 3,5-Dimethylbiphenyl The title compound was obtained as a colorless oil (184 mg, 99% isolated yield) from the reaction of phenylboronic acid (190 mg, 1.56 mmol), CsF (473 mg, 3.12 mmol), Pd(dba)2 (6 mg, 10 μmol), ligand 1 (11 mg, 31 μmol), and 5-chloro-m-xylene (0.14 mL, 1.0 mmol) in toluene at 110° C. for 5 h. TON'100 and TOF'20. 1 H NMR (CDCl3): δ7.64 (d,J=8.1, 2H, ArH), 7.47 (t,J=7.7, 2H, ArH), 7.35 (t, J=7.5, 1H, ArH), 7.27 (s, 2H, ArH), 7.05 (s, 1H, ArH), 2.44 (s, 6H, ArCH3's). 13C{1H} NMR (CDCl3): δ141.5, 141.3, 138.2, 128.9, 128.6, 127.2, 127.0, 125.1, 21.4.
References:
US6268513,2001,B1
108-86-1
524 suppliers
$10.00/5g
98-80-6
753 suppliers
$5.00/5g
591-50-4
503 suppliers
$10.00/1g
98-80-6
753 suppliers
$5.00/5g
