Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate synthesis
- Product Name:Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate
- CAS Number:106820-63-7
- Molecular formula:C9H11NO6S2
- Molecular Weight:293.32
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Yield: 92.3%
Reaction Conditions:
in water; pH=7 - 8 at 20; for 6 h;pH-value;Concentration;
Steps:
1.1 1. Synthesis of 3-((N-(methoxycarbonyl)methyl)sulfonyl)-2-thiophenecarboxylic acid methyl ester
The four-mouth flask equipped with a stirrer was added methyl 3-chlorosulfonyl-2-thiophenecarboxylate 8 g and water 20 ml. At room temperature, add dropwise glycine methyl ester hydrochloride 4.5 g aqueous solution (10 ml). At the same time, add dropwise 10% acid binding agent aqueous solution 30 ml, control pH to 7-8. After the completion of the addition, reaction at room temperature for 6 hours, filtering, the filter cake after the water washing, drying after recrystallization with methanol, getting white solid TNXK-1 to 9 g, yield 92.3%.
References:
Jiangxi Yong Tong Technology Co., Ltd.;Liu Zhongchun CN107141308, 2017, A Location in patent:Paragraph 0041-0045; 0063; 0067; 0073; 0077; 0083; 0087
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106820-63-7
142 suppliers
$12.72/1gm: