ChemicalBook CAS DataBase List Glycine methyl ester hydrochloride

Glycine methyl ester hydrochloride synthesis

12synthesis methods

Product Name:Glycine methyl ester hydrochloride
CAS Number:5680-79-5
Molecular formula:C3H8ClNO2
Molecular Weight:125.55

67-56-1

56-40-6

5680-79-5

(2) Preparation of glycine methyl ester hydrochloride: 60 mL of methanol was added to a 100 mL round-bottomed flask under ice-bath conditions, followed by the slow dropwise addition of 4 mL of sulfoxide chloride (SOCl2) through a constant-pressure dropping funnel (with a drying tube on top). The resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of glycine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using 2% ninhydrin ethanol solution as a color developer until the disappearance of the raw material spot. After completion of the reaction, the solvent was removed by evaporation to give glycine methyl ester hydrochloride in 100% yield.

67-56-1 Synthesis

67-56-1
803 suppliers
$9.00/25ml

56-40-6 Synthesis

56-40-6
1368 suppliers
$5.00/25g

5680-79-5
554 suppliers
$3.66/25g

Yield:5680-79-5 100%

Reaction Conditions:

Stage #1: methanolwith dichloro sulfoxide for 1 h;Cooling with ice;
Stage #2: 2-aminoacetic acid at 20 - 66; for 6.5 h;

Steps:

18.2 (2)
Preparation of glycine methyl ester hydrochloride

(2)
Preparation of glycine methyl ester hydrochloride
Under ice bath, 100 ml round-bottom flask was added with 60 ml of methanol, and then slowly added with 4 ml of SOCl₂ through constant pressure dropping funnel (with a drying tube on the top), and NaOH solution was used to absorb exhaust.
After stirring for 1 h, 8 mmol of glycine was added and stirred at room temperature for 30 min, and then refluxed at 66° C. for 6 h.
The reaction was tracked by TLC until the raw materials disappeared, with a solution of 2% ninhydrin in ethanol as chromogenic reagent.
The solvent was evaporated out to obtain glycine methyl ester hydrochloride. Yield: 100%.

References:

US2014/206741,2014,A1 Location in patent:Paragraph 0131