ChemicalBook CAS DataBase List Sodium glycinate

Sodium glycinate synthesis

4synthesis methods

Product Name:Sodium glycinate
CAS Number:6000-44-8
Molecular formula:C2H6NNaO2
Molecular Weight:99.06

109-83-1

6000-44-8

The general procedure for the synthesis of sodium glycinate from N-methyl-2-hydroxyethylamine is as follows: first, 10 g of Pd-doped copper catalyst (based on dry matter calculations, loaded on Degussa AG, CE 1015 OY/W activated carbon) was suspended in water and, similar to the method of Example 1, added to an autoclave along with 61 g of ethanolamine. Subsequently, 272 g of 15 wt% sodium hydroxide solution was added. After sealing the autoclave, the reaction mixture was heated to 160°C. During the reaction, the system pressure was maintained at 12 bar (absolute pressure) and the generated hydrogen was continuously vented through a pressure control valve. The end point of the reaction was determined by observing a significant decrease in hydrogen release. Upon completion of the reaction, the mixture was cooled to 90 °C and the catalyst was removed by filtration to yield 315 g of filtrate. The content of sodium glycinate in this filtrate was 29.8 wt%, corresponding to 96.7% of the theoretical yield. Finally, the filtered catalyst was suspended in 10 g of water for the next batch.

109-83-1
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6000-44-8
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Yield:6000-44-8 96.7%

Reaction Conditions:

with sodium hydroxide;Pd-doped copper catalyst on active carbon in water at 160; under 9000.9 Torr;

Steps:

10 g (calculated on the basis of the dry substance) of a Pd-doped copper catalyst on active carbon (Degussa AG, CE 1015 OY/W) suspended in water was placed first analogously to example 1 in an autoclave and 61 g ethanolamine and 272 g sodium hydroxide solution (15% by weight) were added. The autoclave was closed and the contents were heated to 160° C. The pressure was kept at 12 bar (absolute) and the hydrogen that formed was continuously discharged by a pressure control valve. After the end of the reaction (which is evident from the decrease in gas release) it was cooled to 90° C. and the catalyst was removed from the product solution by filtration. 315 g filtrate which contained 29.8 g % by weight Na glycinate was obtained (corresponds to a yield of 96.7% of theory).The filtered catalyst was suspended in 10 g water and fed back into subsequent batches.

References:

Thalhammer, Franz;Gastner, Thomas US2009/163739, 2009, A1 Location in patent:Page/Page column 2-3

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