Glycine ethyl ester hydrochloride synthesis
- Product Name:Glycine ethyl ester hydrochloride
- CAS Number:623-33-6
- Molecular formula:C4H9NO2.ClH
- Molecular Weight:139.58
Yield:623-33-6 90.4%
Reaction Conditions:
with dichloro sulfoxide at -10 - 20; for 2 h;Heating / reflux;
Steps:
2.1.1 1. Glycine ethyl ester hydrochloride (Product 2)
247.3 g of thionyl chloride and 130 g of glycine were added at -10 C. to 1000 ml of ethanol. After removing the ice bath a further equivalent amount of glycine was added in portions. The mixture was then stirred for 2 hours under reflux. After cooling to room temperature the excess alcohol and the thionyl chloride were removed on a rotary evaporator. Ethanol was added twice more to the white solid obtained and the ethanol was in turn removed on the rotary evaporator in order completely to remove adhering thionyl chloride. After recrystallisation from ethanol 218.6 g (90.4% of theory) of the title compound (product 2) were obtained.
References:
US2003/236253,2003,A1 Location in patent:Page 12
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