ChemicalBook CAS DataBase List ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE

ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE synthesis

7synthesis methods

Product Name:ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE
CAS Number:107905-52-2
Molecular formula:C9H13F6O5P
Molecular Weight:346.16

KHMDS (7.50 mL, 3.75 mmol, 0.5 M in toluene) was added to a solution of 18- crown-6 (4.10 g, 15.51 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.50 mL, 3.41 mmol) by syringe in a dropwise manner at -78 ℃. Following 15 min, ethyl 2-bromopropionate (0.40 mL, 3.08 mmol) was added to the round bottom flask and the reaction mixture was allowed to stir for 4 hr at room temperature. Following the standard workup procedure, the crude product was then purified by flash column chromatography (3:1 to 2:1 hexanes:EtOAc, Rf = 0.33 in 1:1 hexanes:EtOAc) yielding Ethyl 2-[Bis(2,2,2-trifluoroethyl)phosphono] Propionate (112 mg, 0.33 mmol, 10.5%) as a yellow syrup.

Propanoic acid, 2-[bis[(trimethylsilyl)oxy]phosphinyl]-, ethyl ester

107905-57-7
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ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE

107905-52-2
33 suppliers
$120.00/100mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 77 percent / PCl₅ / 2 h / 80 °C
2: 92 percent / triethylamine / benzene / 0 - 22 °C

References:

Hensel, M. J.;Fuchs, P. L. [Synthetic Communications,1986,vol. 16,p. 1285 - 1296]

75-89-8
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$9.00/1g

Propanoic acid, 2-(dichlorophosphinyl)-, ethyl ester

107905-58-8
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107905-52-2
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$120.00/100mg

References

3699-66-9 Synthesis

3699-66-9
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107905-52-2
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$120.00/100mg

References

541-41-3
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$21.00/5g

650-16-8
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107905-52-2
33 suppliers
$120.00/100mg

References

92466-70-1
53 suppliers
$20.05/1g

41978-69-2
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107905-52-2
33 suppliers
$120.00/100mg

References

ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Related Search:

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ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE synthesis

ETHYL 2-[BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONO] PROPIONATE Related Search: