ChemicalBook CAS DataBase List ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE synthesis

4synthesis methods

Product Name:ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE
CAS Number:124755-24-4
Molecular formula:C8H11F6O5P
Molecular Weight:332.13

To stirred solution of 18-crown-6 (4.40 g, 16.65 mmol), THF (20 mL), and bis (2,2,2-trifluoroethyl) phosphite (1) (0.55 mL, 3.75 mmol), KHMDS (8.0 mL, 4.00 mmol, 0.5 M in toluene) was added via syringe in a dropwise manner at -78 oC. Ethyl chloroacetate (0.35 mL, 3.30 mmol) was added to the flask after 15 min. The reaction flask was allowed to warm to room temperature and stir for 4 hr. After standard workup procedure, the crude product was then purified by flash column chromatography (2:1-1:1 hexanes:EtOAc, Rf = 0.25 in 2:1 hexanes:EtOAc) yielding Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (808 mg, 2.43 mmol, 73.4%) as a yellow syrup.

BIS(2 2 2-TRIFLUOROETHYL)METHYLPHOSPHON&

757-95-9
31 suppliers
$64.59/5g

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE

124755-24-4
92 suppliers
$33.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1: n-BuLi, HMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C
2: aq. HCl

References:

Patois;Savignac;About-Jaudet;Collignon [Synthetic Communications,1991,vol. 21,# 22,p. 2391 - 2396]

FullText

541-41-3
0 suppliers
$19.39/5g

757-95-9
31 suppliers
$64.59/5g

124755-24-4
92 suppliers
$33.00/1g

References

92466-70-1
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$17.10/1g

105-36-2 Synthesis

105-36-2
347 suppliers
$5.00/5 g

124755-24-4
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$33.00/1g

References

75-89-8
499 suppliers
$9.00/1g

Acetic acid, (dichlorophosphinyl)-, ethyl ester

36957-54-7
1 suppliers
inquiry

124755-24-4
92 suppliers
$33.00/1g

References

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Related Search:

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ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE synthesis

ETHYL [BIS(2,2,2-TRIFLUOROETHOXY)PHOSPHINYL]ACETATE Related Search: