1-Piperazinecarboxylic acid, 4-[1-(3-methoxy-4-nitrophenyl)-4-piperidinyl]-, 1,1-dimethylethyl ester synthesis
- Product Name:1-Piperazinecarboxylic acid, 4-[1-(3-methoxy-4-nitrophenyl)-4-piperidinyl]-, 1,1-dimethylethyl ester
- CAS Number:1089279-66-2
- Molecular formula:C21H32N4O5
- Molecular Weight:420.5
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Yield:1089279-66-2 87%
Reaction Conditions:
with potassium carbonate in acetonitrile at 90; for 15 h;
Steps:
Intermediate 8 tert-Butyl 4-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)piperazine-1-carboxylate tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate (1.842 g, 6.84 mmol) was added to a stirring mixture of 4-fluoro-2-methoxy-1-nitrobenzene (1.17 g, 6.84 mmol) and K2CO3 (2.83 g, 20.51 mmol) in acetonitrile (15 mL) and the reaction mixture was stirred at 90° C. for 15 h. The reaction mixture was filtered and concentrated in vacuo. The crude residue was purified by chromatography on silica gel (hexanes/EtOAc) to give the title product (2.5 g, 87%). m/z 421.
References:
US2012/28924,2012,A1 Location in patent:Page/Page column 25
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