5-AMINO-1-[5-(FLUOROMETHYL)PHENYL]-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER synthesis
- Product Name:5-AMINO-1-[5-(FLUOROMETHYL)PHENYL]-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CAS Number:110821-29-9
- Molecular formula:C13H12F3N3O2
- Molecular Weight:299.25
Yield:110821-29-9 66%
Reaction Conditions:
in ethanol; for 24 h;Reflux;Inert atmosphere;
Steps:
234
To a solution of ethyl 2-cyano-3-ethoxyacrylate (0.81 g, 4.8 mmol) in ethanol (50 mL) was added 3-(trifluoromethyl)phenylhydrazine (0.85g, 4.8 mmol). The resultant reaction mixture was refluxed for 24 hours under a nitrogen atmosphere. The mixture was cooled to room temperature and concentrated under reduced pressure to afford 0.94 g (yield: 66 %), which was used without further purification. MS (ESI) m/z :300.3
References:
WO2010/51549,2010,A1 Location in patent:Page/Page column 152
98-16-8
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