2-cyano-3-ethoxyacrylic acid synthesis
2synthesis methods
- Product Name:2-cyano-3-ethoxyacrylic acid
- CAS Number:71648-24-3
- Molecular formula:C6H7NO3
- Molecular Weight:141.12
![5-AMINO-1-[5-(FLUOROMETHYL)PHENYL]-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/110821-29-9.gif)
Yield:110821-29-9 66%
Reaction Conditions:
in ethanol; for 24 h;Reflux;Inert atmosphere;
Steps:
234
To a solution of ethyl 2-cyano-3-ethoxyacrylate (0.81 g, 4.8 mmol) in ethanol (50 mL) was added 3-(trifluoromethyl)phenylhydrazine (0.85g, 4.8 mmol). The resultant reaction mixture was refluxed for 24 hours under a nitrogen atmosphere. The mixture was cooled to room temperature and concentrated under reduced pressure to afford 0.94 g (yield: 66 %), which was used without further purification. MS (ESI) m/z :300.3
References:
WO2010/51549,2010,A1 Location in patent:Page/Page column 152
