CPhos synthesis
- Product Name:CPhos
- CAS Number:1160556-64-8
- Molecular formula:C28H41N2P
- Molecular Weight:436.61
1160556-63-7
16 suppliers
$53.00/250mg
16523-54-9
282 suppliers
$8.00/1g
1160556-64-8
102 suppliers
$32.00/100mg
Yield:1160556-64-8 87%
Reaction Conditions:
Stage #1:2'-bromo-N2,N2,N6,N6-tetramethyl-[1,1'-biphenyl]-2,6-diamine with n-butyllithium in tetrahydrofuran;hexane at -78; for 0.75 h;Inert atmosphere;
Stage #2:chlorodicyclohexylphosphane in tetrahydrofuran;hexane at -78 - 20;
References:
Han, Chong;Buchwald, Stephen L. [Journal of the American Chemical Society,2009,vol. 131,p. 7532 - 7533] Location in patent:supporting information; experimental part