Silane, (4-chlorophenoxy)(1,1-dimethylethyl)dimethyl- synthesis
- Product Name:Silane, (4-chlorophenoxy)(1,1-dimethylethyl)dimethyl-
- CAS Number:126644-72-2
- Molecular formula:C12H19ClOSi
- Molecular Weight:242.8172
Yield:126644-72-2 100%
Reaction Conditions:
with 1H-imidazole in N,N-dimethyl-formamide at 20;
Steps:
2. General procedure for synthesis of aryl TBDMS ethers
To the stirred solution of Phenol (1 mmol) in DMF (5 volume) was added imidazole (2 mmol) at room temperature and after 5 minutes TBDMS chloride (1.2mmol) was added and stirring continued untill completion of reaction (TLC monitoring).Next, charged water (5 volumes) to the reactio mass and extracted with diethyl ether (2X10 volumes). The combined organic layer was washed with brine(5 vol), dried (Na2SO4)and concentrated under vacuumwhich gave respective aryl TBDMS ethers in quantitative yields.
References:
Dond, Bharat D.;Thore, Shivaji N. [Tetrahedron Letters,2020] Location in patent:supporting information
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