4-bromo-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one synthesis
- Product Name:4-bromo-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one
- CAS Number:1361481-63-1
- Molecular formula:C8H7BrN2O
- Molecular Weight:227.06
![4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one](/CAS/20200401/GIF/1445993-87-2.gif)
1445993-87-2
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Yield: 100%
Reaction Conditions:
with sodium hydride in ethanol;water at 20; for 16 h;
Steps:
30.1; 31.1 4-bromo-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
A solution of 4-bromo-6-methyl- 1 -[(4-methylphe- nyl)sulfonyl]- 1 ,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one (5.81 g, 15.2 mmol) in ethanol (100 mE) was treated with 3.0 M sodium hydroxide in water (50.8 mE, 152 mmol) and stirred at 20° C. for 16 h. The reaction mixture was concentrated in vacuo to remove most of the ethanol. The remaining aqueous layer was neutralized with concentrated HC1 to pH -7 and extracted with ethyl acetate (2x). The combined organic layers were dried with magnesium sulfate, filtered, and concentrated to give the desired product (3.74 g, quantitative) which was used without further purification. LCMS calculated for C8H813rN2O (M+H): mlz=227.0, 229.0. found: 227.0, 228.9.
References:
INCYTE CORPORATION;Yue, Eddy W.;Combs, Andrew P.;Douty, Brent US2015/148342, 2015, A1 Location in patent:Paragraph 0409; 0410
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